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说明： Dual BRD4 and CBP/p300 bromodomain inhibitor
化学名： [3-[4-[2-[5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-1,3-benzodiazol-2-yl]ethyl]phenoxy]propyl]dimethylamine
纯度： ≥98% (HPLC)
生物活性 for ISOX DUAL
ISOX DUAL is a dual CBP/p300 and BRD4 bromodomain inhibitor (IC50 values are 0.65 and 1.5 μM for CBP and BRD4 respectively). Downregulates IL-6, IL-1β and IFN-β in macrophages.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for ISOX DUAL
| 分子量 | 531.69 |
| 公式 | C31H41N5O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1962928-22-8 |
| PubChem ID | 121237857 |
| InChI Key | HCDQWCDANVEBQR-UHFFFAOYSA-N |
| Smiles | CC(ON=C1C)=C1C2=CC(N=C(CCC3=CC=C(OCCCN(C)C)C=C3)N4CCN5CCOCC5)=C4C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ISOX DUAL
参考文献 for ISOX DUAL
参考文献是支持产品生物活性的出版物。
Chekler (2015) Transcriptional profiling of a selective CREB binding protein bromodomain inhibitor highlights therapeutic opportunities. Chem.Biol. 22 1588 PMID: 26670081
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关键词: ISOX DUAL, ISOX DUAL supplier, Dual, CBP/p300, BRD4, bromodomains, inhibitors, inflammation, macrophages, inhibits, Bromodomains, Histone, Acetyltransferases, 5806, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
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