Isradipine

Cat. No. 2004 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Ca_V1.x blocker

别名： PN 200-110

化学名： 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester

纯度： ≥98% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Isradipine

Isradipine is a potent and selective L-type voltage-gated Ca²⁺ channel blocker. EC₅₀ and pA₂ values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca²⁺-induced contractions of rabbit aorta respectively; EC₂₅ = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo, exerting primary effects on vascular tissue with secondary negative chronotropic action.

化合物库 for Isradipine

Isradipine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Isradipine

分子量	371.39
公式	C₁₉H₂₁N₃O₅
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	75695-93-1
PubChem ID	3784
InChI Key	HMJIYCCIJYRONP-UHFFFAOYSA-N
Smiles	COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC2=NON=C12)C(=O)OC(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Isradipine

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	18.57	50
	ethanol	7.43	20

制备储备液 for Isradipine

以下数据基于产品分子量 371.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	5.39 mL	26.93 mL	53.85 mL
2.5 mM	1.08 mL	5.39 mL	10.77 mL
5 mM	0.54 mL	2.69 mL	5.39 mL
25 mM	0.11 mL	0.54 mL	1.08 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for Isradipine

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Isradipine

参考文献是支持产品生物活性的出版物。

Hof et al (1984) PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta. J.Cardiovasc.Pharmacol. 6 399 PMID: 6202964

Wada et al (1985) Separation of the coronary vasodilator from the cardiac effects of PN 200-110, a new dihydropyridine calcium antagonist, in the dog heart. J.Cardiovasc.Pharmacol. 7 190 PMID: 2580142

Ruegg and Hof (1990) Pharmacology of the calcium antagonist israd. Drugs 40 3

If you know of a relevant reference for Isradipine, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Ca_V1.x Channel (L-type) Blockers

关键词: Isradipine, Isradipine supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, PN200110, PN, 200-110, Cav1.x, 2004, Tocris Bioscience