ISX 9

Cat. No. 4439 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

化学名： N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide

纯度： ≥98% (HPLC)

说明书

引用文献 (3)

实验方案 (1)

文献 (7)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ISX 9

ISX 9 is a neurogenic agent. Mediates neuroD reporter gene induction via activation of Ca²⁺ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. ISX 9 is also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro. When used in combination with other small molecules, ISX 9 directs differentiation of pancreatic progenitors towards β cells.

ISX 9 synthesized to Ancillary Material Grade also available.

For more information about how ISX 9 may be used, see our protocol: Transdifferentiating Fibroblasts into Neurons.

化合物库 for ISX 9

ISX 9 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for ISX 9

分子量	234.27
公式	C₁₁H₁₀N₂O₂S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	832115-62-5
PubChem ID	19582717
InChI Key	SYENTKHGMVKGAQ-UHFFFAOYSA-N
Smiles	O=C(NC2CC2)C1=NOC(C3=CC=CS3)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ISX 9

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	23.43	100
	ethanol	11.71	50

制备储备液 for ISX 9

以下数据基于产品分子量 234.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.27 mL	21.34 mL	42.69 mL
5 mM	0.85 mL	4.27 mL	8.54 mL
10 mM	0.43 mL	2.13 mL	4.27 mL
50 mM	0.09 mL	0.43 mL	0.85 mL

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产品说明书 for ISX 9

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ISX 9

参考文献是支持产品生物活性的出版物。

Schneider et al (2008) Small-molecule activation of neuronal cell fate. Nat.Chem.Biol 4 408 PMID: 18552832

Dioum et al (2011) A small molecule differentiation inducer increases Ins production by pancreatic β cells. Proc.Natl.Acad.Sci.U.S.A. 108 20713 PMID: 22143803

Zhang et al (2011) Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. Differentiation 81 233 PMID: 21419563

Russell et al (2012) Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem.Biol. 7 1067 PMID: 22413910

Liu et al (2021) Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells. Nat.Commun. 12 3330 PMID: 34099664

If you know of a relevant reference for ISX 9, please let us know.

按标靶查看相关产品

关键词: ISX 9, ISX 9 supplier, ISX9, isoxazoles, neurogenic, neuronal, differentiation, neuroD1, CaMKII, MEF2, neurogenesis, Isx1, NeuroD1, Neuronal, differentiator, inducer, III, beta, β, cells, cardiomyocyte, Neural, Stem, Cells, Cardiomyocyte, Organoids, 4439, Tocris Bioscience

3 篇 ISX 9 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ISX 9 的部分引用包括：

Xie et al (2018) β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming. PLoS Genet 14 e1007846 PMID: 30557298

Pujol et al (2018) Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function. Int J Mol Sci 19 PMID: 30150605

Koh et al (2015) Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells. PLoS One 10 e0138724 PMID: 26407349

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ISX 9 实验方案

以下实验方案包含使用 ISX 9（目录编号 4439）的更多信息。

Transdifferentiating Fibroblasts into Neurons

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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