ITE

Cat. No. 1803 9 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Endogenous agonist for the transcription factor aryl hydrocarbon receptor

别名： Aryl hydrocarbon receptor ligand

化学名： 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester

纯度： ≥98% (HPLC)

引用文献 (9)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ITE

ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (K_i = 3 nM). Decreases Oct4 levels in U87 glioblastoma cells. Induces stem-like cancer cell differentiation in U87 tumor spheres and inhibits ovarian cancer cell proliferation in vitro. Suppresses tumor growth in U87 and OVCAR-3 cell xenografts in mice. Also inhibits TGF-β-induced human myofibroblast differentiation.

化合物库 for ITE

ITE is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for ITE

分子量	286.3
公式	C₁₄H₁₀N₂O₃S
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	448906-42-1
PubChem ID	4668801
InChI Key	KDDXOGDIPZSCTM-UHFFFAOYSA-N
Smiles	COC(=O)C1=CSC(=N1)C(=O)C1=CNC2=CC=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ITE

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	28.63	100

制备储备液 for ITE

以下数据基于产品分子量 286.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.49 mL	17.46 mL	34.93 mL
5 mM	0.7 mL	3.49 mL	6.99 mL
10 mM	0.35 mL	1.75 mL	3.49 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

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产品说明书 for ITE

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ITE

参考文献是支持产品生物活性的出版物。

Song et al (2002) A ligand for the aryl hydrocarbon receptor isolated from lung. Proc.Natl.Acad.Sci.U.S.A. 99 14694 PMID: 12409613

Lehmann et al (2011) The aryl hydrocarbon receptor ligand ITE inhibits TGF beta 1-induced human myofibroblast differentiation. Am.J.Pathol. 178 1556 PMID: 21406171

Cheng et al (2015) Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells. Nat.Commun. 6 7209 PMID: 26059097

Wang et al (2013) An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells. Cancer Lett. 340 63 PMID: 23851185

If you know of a relevant reference for ITE, please let us know.

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