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Itraconazole

Cat. No. 5981 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)
化学名： 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Itraconazole

Itraconazole is a SMO antagonist (IC50 = 690 nM); acts at different binding site to cyclopamine (Cat. No. 1623). Also cytochrome p450 inhibitor (IC50 = 16-26 nM). Inhibits cell cycle at G1 phase in vitro and blocks angiogenesis in vivo (IC50 = 160 nM). Antifungal.

技术数据 for Itraconazole

分子量 705.63
公式 C35H38Cl2N8O4
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 84625-61-6
PubChem ID 3793
InChI Key OPJPKRNKYPEBBY-YFWMVZQVSA-N
Smiles CCC(N1N=CN(C2=CC=C(N3CCN(C4=CC=C(C=C4)OC[C@H]5CO[C@@](O5)(C6=C(C=C(C=C6)Cl)Cl)CN7C=NC=N7)CC3)C=C2)C1=O)C.CCC(N8N=CN(C9=CC=C(N%10CCN(C%11=CC=C(C=C%11)OC[C@@H]%12CO[C@](O%12)(C%13=C(C=C(C=C%13)Cl)Cl)CN%14C=NC=N%14)CC%10)C=C9)C8=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Itraconazole

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 14.11 20 温和加热

制备储备液 for Itraconazole

以下数据基于产品分子量 705.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 7.09 mL 35.43 mL 70.86 mL
1 mM 1.42 mL 7.09 mL 14.17 mL
2 mM 0.71 mL 3.54 mL 7.09 mL
10 mM 0.14 mL 0.71 mL 1.42 mL

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参考文献 for Itraconazole

参考文献是支持产品生物活性的出版物。

Chong et al (2007) Inhibition of angiogenesis by the antifungal drug itracon. ACS Chem.Biol. 2 263 PMID: 17432820

Kim et al (2013) Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell 23 23 PMID: 23291299

Kim et al (2010) Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 17 388 PMID: 20385363

Pace et al (2016) Repurposing the clinically efficacious antifungal agent itracon. as an anticancer chemotherapeutic. J.Med.Chem. 59 3635 PMID: 27014922

If you know of a relevant reference for Itraconazole, please let us know.

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关键词: Itraconazole, Itraconazole supplier, SMO, antagonists, smoothened, receptors, cytochrome, p450, inhiibitors, inhibits, cell, cycle, angiogenesis, antifungals, hedgehog, Smoothened, Receptors, Antiangiogenics, Cell, Cycle, Inhibitors, Antifungals, 5981, Tocris Bioscience

2 篇 Itraconazole 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Itraconazole 的部分引用包括：

Amit et al (2022) Nucleoli in epithelial cell collectives respond to tumorigenic, spatial, and mechanical cues. Mol Biol Cell 33 br19 PMID: 35830599

Jonathan S et al (2020) Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells. Elife 9 PMID: 33174843

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