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说明： Selective TrioN RhoGEF activity inhibitor
化学名： (E)-2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]thiazolo[3,2-a]benzimidazol-3(2H)-one
纯度： ≥99% (HPLC)
生物活性 for ITX 3
ITX 3 is a selective inhibitor of TrioN RhoGEF activity. Inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro.
技术数据 for ITX 3
| 分子量 | 371.45 |
| 公式 | C22H17N3OS |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 347323-96-0 |
| PubChem ID | 1362865 |
| InChI Key | SJMYMKPBODEZSH-DEDYPNTBSA-N |
| Smiles | CC4=C(C=C(C)N4C5=CC=CC=C5)\C=C3/C(N2C1=CC=CC=C1N=C2S3)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ITX 3
参考文献 for ITX 3
参考文献是支持产品生物活性的出版物。
Bouquier et al (2009) A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem.Biol. 16 657 PMID: 19549603
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关键词: ITX 3, ITX 3 supplier, ITX3, selective, TrioN, RhoGEFs, guanine, nucleotide, exchange, factors, inhibitors, inhibits, RhoG, Rac1, GTPases, small, G, proteins, Rho, 3792, Tocris Bioscience
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