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Submit ReviewIvabradine hydrochloride
说明： HCN channel blocker; inhibits If pacemaker current
化学名： 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Ivabradine hydrochloride
Ivabradine hydrochloride is a HCN channel blocker (IC50 is approximately 0.5 - 2.5 μM). Bradycardic agent that inhibits If pacemaker current in sinoatrial node cells.
化合物库 for Ivabradine hydrochloride
Ivabradine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Ivabradine hydrochloride
| 分子量 | 505.05 |
| 公式 | C27H36N2O5.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 148849-67-6 |
| PubChem ID | 3045381 |
| InChI Key | HLUKNZUABFFNQS-ZMBIFBSDSA-N |
| Smiles | COC1=C(C=C2[C@H](CC2=C1)CN(CCCN3CCC4=CC(OC)=C(C=C4CC3=O)OC)C)OC.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ivabradine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 50.51 | 100 | |
| DMSO | 50.51 | 100 |
制备储备液 for Ivabradine hydrochloride
以下数据基于产品分子量 505.05。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.98 mL | 9.9 mL | 19.8 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 10 mM | 0.2 mL | 0.99 mL | 1.98 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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产品说明书 for Ivabradine hydrochloride
参考文献 for Ivabradine hydrochloride
参考文献是支持产品生物活性的出版物。
Thollon et al (1994) Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. Br.J.Pharmacol. 112 37 PMID: 8032660
Novella Romanelli et al (2016) HCN channel modulators: the need for selectivity. Curr.Top.Med.Chem. 16 1764 PMID: 26975509
If you know of a relevant reference for Ivabradine hydrochloride, please let us know.
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关键词: Ivabradine hydrochloride, Ivabradine hydrochloride supplier, Ivabradine, HCL, HCN, blockers, blocks, bradycardic, agents, hyperpolarization, activated, current, If, inhibitors, inhibits, pacemaker, Channels, 6542, Tocris Bioscience
1 篇 Ivabradine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ivabradine hydrochloride 的部分引用包括：
Joseph J et al (2020) BRAFV600E expression in neural progenitors results in a hyperexcitable phenotype in neocortical pyramidal neurons. J Neurophysiol 123 2449-2464 PMID: 32401131
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Ivabradine hydrochloride 的评论
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Effect of ivabradine on pacemaker of human atrial myocytes.
By
Chintan Koyani on 10/13/2018
分析类型： In Vitro
种属： Human
细胞系/组织： primary atrial cardiomyocytes
Primary human atrial cardiomyocytes were patched to analyze mean current-voltage relationships of pacemaker current (If) before and after ivabradine superfusion (1 μmol/L, 7 min). Ivabradine significantly reduced pacemaker current density (pA/pF) from − 80 to − 130 mV (shown in Image).
