主页 / 药理学 / Enzymes / Transferases / PORCN / PORCN Inhibitors / IWP L6

IWP L6

Cat. No. 4992 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent PORCN inhibitor
化学名： N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for IWP L6

IWP L6 is a potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM). Shown to inhibit Wnt-dependent processes such as tailfin regeneration and posterior axis formation in zebrafish; also reduces branching morphogenesis in cultured mouse embryonic kidneys.

技术数据 for IWP L6

分子量 472.58
公式 C25H20N4O2S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1427782-89-5
PubChem ID 71601111
InChI Key QESQGTFWEQMCMH-UHFFFAOYSA-N
Smiles O=C1C3=C(CCS3)N=C(SCC(NC4=NC=C(C5=CC=CC=C5)C=C4)=O)N1C2=CC=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for IWP L6

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.26 100

制备储备液 for IWP L6

以下数据基于产品分子量 472.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.58 mL 21.16 mL
5 mM 0.42 mL 2.12 mL 4.23 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for IWP L6

参考文献是支持产品生物活性的出版物。

Wang et al (2013) The development of highly potent inhibitors for Porcupine. J.Med.Chem. 56 2700 PMID: 23477365

If you know of a relevant reference for IWP L6, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 PORCN Inhibitors

关键词: IWP L6, IWP L6 supplier, IWPL6, MBOAT, membrane-bound, O-acyltransferases, inhibitors, inhibits, porcupine, porcn, Wnt, PORCN, 4992, Tocris Bioscience

篇 IWP L6 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 IWP L6 的引用文献。 您是否知道使用了 Tocris IWP L6 的优秀论文？ 请告知我们.

IWP L6 的评论

目前没有该产品的评论。 Be the first to review IWP L6 and earn rewards!

Have you used IWP L6?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review