J 104129 fumarate

Cat. No. 2507 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective M₃ antagonist

化学名： (αR)-α-Cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate

纯度： ≥99% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for J 104129 fumarate

J 104129 fumarate is a potent M₃ muscarinic receptor antagonist that displays ~ 120-fold selectivity over M₂ receptors (K_i values are 4.2, 19 and 490 nM for human M₃, M₁ and M₂ receptors respectively). Exhibits > 250-fold bronchial selectivity; inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (K_B values are 3.3 and 170 nM for rat trachea M₃ and rat right atria M₂ receptors respectively).

化合物库 for J 104129 fumarate

J 104129 fumarate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for J 104129 fumarate

分子量	500.63
公式	C₂₄H₃₆N₂O₂.C₄H₄O₄
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	257603-40-0
PubChem ID	56972189
InChI Key	HUCQUCITPHOUAC-DSSYAJFBSA-N
Smiles	[H]OC(=O)\C=C\C(=O)O[H].C\C(C)=C\CCN1CCC(CC1)NC(=O)[C@@](O)(C1CCCC1)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for J 104129 fumarate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	50.06	100
	ethanol	25.03	50

制备储备液 for J 104129 fumarate

以下数据基于产品分子量 500.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2 mL	9.99 mL	19.97 mL
5 mM	0.4 mL	2 mL	3.99 mL
10 mM	0.2 mL	1 mL	2 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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产品说明书 for J 104129 fumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for J 104129 fumarate

参考文献是支持产品生物活性的出版物。

Mitsuya et al (1999) J-104129, a novel muscarinic M₃ receptor antagonist with high selectivity for M₃ over M₂ receptors. Bioorg.Med.Chem. 7 2555 PMID: 10632066

Mitsuya et al (2000) Discovery of a muscarinic M₃ receptor antagonist with high selectivity for M₃ over M₂ receptors among 2-[(1S,3S)-3-sulfonylaminocyclopentyl]phenylacetamide derivatives. Bioorg.Med.Chem. 8 825 PMID: 10819171

Mitsuya et al (1999) Stereoselective synthesis of a new muscarinic M₃ receptor antagonist, J-104129. Bioorrg.Med.Chem.Lett. 9 2037

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关键词: J 104129 fumarate, J 104129 fumarate supplier, Potent, selective, M3, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, J104129, fumarate, 2507, Tocris Bioscience

1 篇 J 104129 fumarate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 J 104129 fumarate 的部分引用包括：

Bader and Diener (2015) Novel aspects of cholinergic regulation of colonic ion transport. Biomed Res Int 3 e00139 PMID: 26236483

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