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(±)-J 113397

Cat. No. 2598 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective NOP antagonist
化学名： (±)-1-[(3R*,4R*)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (±)-J 113397

(±)-J 113397 is a potent and selective NOP receptor antagonist (IC50 values are 2.3, 1400, 2200 and > 10000 nM for NOP, κ, μ and δ-opioid receptors respectively). Inhibits nociceptin/orphanin FQ-induced hyperalgesia in the mouse tail-flick test.

化合物库 for (±)-J 113397

(±)-J 113397 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for (±)-J 113397

分子量 399.57
公式 C24H37N3O2
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 217461-40-0
PubChem ID 90488772
InChI Key NLSVMRCGZVSAFK-SDNSQTLOSA-N
Smiles CCN1C4=C(C=CC=C4)N([C@@H]2CCN(CC3CCCCCCC3)C[C@H]2CO)C1=O.CCN5C8=C(C=CC=C8)N([C@H]6CCN(CC7CCCCCCC7)C[C@@H]6CO)C5=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (±)-J 113397

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 19.98 50
ethanol 19.98 50

制备储备液 for (±)-J 113397

以下数据基于产品分子量 399.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.01 mL 25.03 mL 50.05 mL
2.5 mM 1 mL 5.01 mL 10.01 mL
5 mM 0.5 mL 2.5 mL 5.01 mL
25 mM 0.1 mL 0.5 mL 1 mL

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产品说明书 for (±)-J 113397

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关键词: (±)-J 113397, (±)-J 113397 supplier, Potent, selective, NOP, antagonists, Nociceptin, Receptors, ORL1, OP4, Opioid, J113397, 2598, Tocris Bioscience

1 篇 (±)-J 113397 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (±)-J 113397 的部分引用包括：

Wen et al (2011) Pharmacological mechanisms underlying the antinociceptive and tolerance effects of the 6,14-bridged oripavine compound 030418. Acta Pharmacol Sin 32 1215 PMID: 21863064

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