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JBJ-03-142-02

Cat. No. 6962 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors
化学名： (4-Fluorophenyl)methyl N-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-N-[3-[(1-oxo-2-propen-1-yl)amino]phenyl]carbamate
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for JBJ-03-142-02

JBJ-03-142-02 is a highly potent epidermal growth factor receptor (EGFR) and ErbB2 (human epidermal growth factor receptor; HER2) inhibitor. Inhibits wild type and tumorgenic mutated receptors (exon 20 insertion; Ex20Ins). Antiproliferative in vitro (IC50 values are 7.6, 30 - 95, 3.8 and 19 - 31 nM for Ba/F3 cells expressing wild type EGFR, EGFR with Ex20Ins mutation, wild type HER2 and HER2 with Ex20Ins mutation, respectively). Also inhibits other common EGFR mutants. Antiproliferative in patient-derived lung cancer cell lines.

许可信息

Sold under license from Dana-Farber Cancer Institute

技术数据 for JBJ-03-142-02

分子量 487.5
公式 C25H22FN7O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2068806-31-3
PubChem ID 126496758
InChI Key IFRXGTCPIGRGHP-UHFFFAOYSA-N
Smiles CN1C=C(NC2=NC=CC(=N2)N(C(=O)OCC2=CC=C(F)C=C2)C2=CC(NC(=O)C=C)=CC=C2)C=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JBJ-03-142-02

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.37 50

制备储备液 for JBJ-03-142-02

以下数据基于产品分子量 487.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.1 mL 20.51 mL 41.03 mL
2.5 mM 0.82 mL 4.1 mL 8.21 mL
5 mM 0.41 mL 2.05 mL 4.1 mL
25 mM 0.08 mL 0.41 mL 0.82 mL

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参考文献 for JBJ-03-142-02

参考文献是支持产品生物活性的出版物。

Jang et al (2018) Discovery of a highly potent and broadly effective epidermal growth factor receptor and HER2 exon 20 insertion mutant inhibitor. Angew.Chem.Int.Ed.Engl. 57 11629 PMID: 29978938

If you know of a relevant reference for JBJ-03-142-02, please let us know.

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关键词: JBJ-03-142-02, JBJ-03-142-02 supplier, JBJ0314202, mutated, EGFR, GER2, ErbB2, inhibitors, inhibits, highly, potent, epidermal, growth, factor, receptor, 6962, Tocris Bioscience

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