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JH-II-127

Cat. No. 6289 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective LRRK2 inhibitor
化学名： [4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for JH-II-127

JH-II-127 is a potent and selective LRRK2 inhibitor (IC50 values are 2.2, 6.6 and 47.7 nM for G2019S-mutant, wild-type and A2016T-mutant LRRK2, respectively). Selective for LRRK2 over a panel of 138 kinases. Brain penetrant and orally bioavailable.

许可信息

Sold under license from Dana-Farber Cancer Institute.

化合物库 for JH-II-127

JH-II-127 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for JH-II-127

分子量 416.87
公式 C19H21ClN6O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1700693-08-8
PubChem ID 112499966
InChI Key HUEKBQXFNHWTQQ-UHFFFAOYSA-N
Smiles O=C(N1CCOCC1)C2=CC(OC)=C(NC3=NC(NC)=C(C(Cl)=CN4)C4=N3)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JH-II-127

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.69 100

制备储备液 for JH-II-127

以下数据基于产品分子量 416.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.4 mL 11.99 mL 23.99 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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参考文献 for JH-II-127

参考文献是支持产品生物活性的出版物。

Hatcher et al (2015) Discovery of a pyrrolopyrimidine (JH-II-127), a highly potent, selective, and brain penetrant LRRK2 inhibitor. ACS Med.Chem.Lett. 6 584 PMID: 26005538

If you know of a relevant reference for JH-II-127, please let us know.

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关键词: JH-II-127, JH-II-127 supplier, potent, selective, Leucine-rich, repeat, kinase, 2, LRRK2, inhibitor, inhibits, orally, bioavaillable, brain, penetrant, Parkinson's, parkinsons, 6289, Tocris Bioscience

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