Jingzhaotoxin III

Cat. No. 4913 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective Na_V1.5 channel blocker

纯度： ≥95% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Jingzhaotoxin III

Jingzhaotoxin III is a selective blocker of Na_V1.5 channels (IC₅₀ = 348 nM); displays no effect on other isoforms, including Na_V1.2, Na_V1.4, Na_V1.6 and Na_V1.7. Thought to inhibit sodium channel activation by binding to the Na_V1.5 S3-S4 linker of domain II. Selectively inhibits the activation of cardiac sodium channels, but has no effect on sodium channels in dorsal root ganglion neurons.

技术数据 for Jingzhaotoxin III

分子量	3919.5
公式	C₁₇₄H₂₄₁N₄₇O₄₆S₆
序列	DGECGGFWWKCGRGKPPCCKGYACSKTWGWCAVEAP (Modifications: Disulfide bridges: 4-19, 11-24, 18-31)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	925463-91-8
PubChem ID	90488988
InChI Key	OKELXNUZHJLTAQ-UHFFFAOYSA-N
Smiles	[H]N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)CNC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)CNC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)CNC(=O)[C@H](CCCCN)NC2=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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溶解性数据 for Jingzhaotoxin III

溶解性	Soluble to 1 mg/ml in water

产品说明书 for Jingzhaotoxin III

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Jingzhaotoxin III

参考文献是支持产品生物活性的出版物。

Xiao et al (2004) Jingzhaotoxin-III, a novel spider toxin inhibiting activation of sodium channel in rat cardiac myocytes. J.Biol.Chem. 279 26220 PMID: 15084603

Rong et al (2011) Molecular basis of the tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) interacting with voltage sensors in sodium channel subtype Nav1.5. FASEB J. 25 3177 PMID: 21665957

If you know of a relevant reference for Jingzhaotoxin III, please let us know.

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