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Submit ReviewJMS 17-2 hydrochloride
说明： CX3CR1 antagonist
化学名： 5-[3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl]pyrrolo[1,2-a]quinoxalin-4(5H)-one hydrochloride
纯度： ≥98% (HPLC)
生物活性 for JMS 17-2 hydrochloride
JMS 17-2 hydrochloride is a chemokine CX3CR1 (fractalkine receptor) antagonist. Inhibits fractalkine-induced ERK phosphorylation and decreases migration of breast cancer cells in vitro. Also inhibits circulating tumor cells from seeding into bone and reduces overall tumor burden in a breast cancer metastasis model.
许可信息
Sold under license from Drexel University.
化合物库 for JMS 17-2 hydrochloride
JMS 17-2 hydrochloride is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for JMS 17-2 hydrochloride
| 分子量 | 456.41 |
| 公式 | C25H26ClN3O.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2341841-07-2 |
| Smiles | ClC1=CC=C(C2CCN(CC2)CCCN3C(C4=CC=CN4C5=CC=CC=C35)=O)C=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for JMS 17-2 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 45.64 | 100 | |
| ethanol | 22.82 | 50 |
制备储备液 for JMS 17-2 hydrochloride
以下数据基于产品分子量 456.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.19 mL | 10.96 mL | 21.91 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.38 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.19 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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产品说明书 for JMS 17-2 hydrochloride
参考文献 for JMS 17-2 hydrochloride
参考文献是支持产品生物活性的出版物。
Shen et al (2016) Novel small-molecule CX3CR1 antagonist impairs metastatic seeding and colonization of breast cancer cells. Mol. Cancer Res. 14 518 PMID: 27001765
If you know of a relevant reference for JMS 17-2 hydrochloride, please let us know.
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关键词: JMS 17-2 hydrochloride, JMS 17-2 hydrochloride supplier, JMS17-2, hydrochloride, HCl, 1380392-05-1, fractalkine, receptor, antagonists, antagonism, cx3cr1, chemokines, Other, Chemokine, Receptors, 6378, Tocris Bioscience
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