JNJ 10191584 maleate

Cat. No. 2441 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective H₄ antagonist; orally active

别名： VUF 6002

化学名： 1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate

纯度： ≥99% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for JNJ 10191584 maleate

JNJ 10191584 maleate is a highly selective histamine H₄ receptor silent antagonist; binds with high affinity to the human H₄ receptor (K_i = 26 nM). > 540-fold selective over the H₃ receptor (K_i = 14.1 μM). Inhibits mast cell and eosinophil chemotaxis in vitro with IC₅₀ values of 138 and 530 nM respectively. Orally active in vivo.

化合物库 for JNJ 10191584 maleate

JNJ 10191584 maleate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for JNJ 10191584 maleate

分子量	394.81
公式	C₁₃H₁₅ClN₄O.C₄H₄O₄
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	869497-75-6
PubChem ID	11718163
InChI Key	KOTJFAYEELTYCZ-BTJKTKAUSA-N
Smiles	O=C(O)/C=C\C(O)=O.ClC(C=C3)=CC2=C3N=C(N2)C(N1CCN(C)CC1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JNJ 10191584 maleate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	19.74	50

制备储备液 for JNJ 10191584 maleate

以下数据基于产品分子量 394.81。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	5.07 mL	25.33 mL	50.66 mL
2.5 mM	1.01 mL	5.07 mL	10.13 mL
5 mM	0.51 mL	2.53 mL	5.07 mL
25 mM	0.1 mL	0.51 mL	1.01 mL

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产品说明书 for JNJ 10191584 maleate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for JNJ 10191584 maleate

参考文献是支持产品生物活性的出版物。

Terzioglu et al (2004) Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H₄ receptor antagonists. Bioorg.Med.Chem.Lett. 14 5251 PMID: 15454206

Venable et al (2005) Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine H₄ antagonists. J.Med.Chem. 48 8289 PMID: 16366610

Varga et al (2005) Inhibitory effects of histamine H₄ receptor antagonists on experimental colitis in the rat. Eur.J.Pharmacol. 522 130 PMID: 16213481

If you know of a relevant reference for JNJ 10191584 maleate, please let us know.

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关键词: JNJ 10191584 maleate, JNJ 10191584 maleate supplier, Selective, H4, receptor, antagonists, orally, active, Receptors, Histamine, histaminergic, JNJ10191584, maleate, VUF6002, silent, antagonist, VUF, 6002, 2441, Tocris Bioscience

3 篇 JNJ 10191584 maleate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 JNJ 10191584 maleate 的部分引用包括：

Desmadryl et al (2012) Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability. Br J Pharmacol 167 905 PMID: 22624822

Connelly et al (2009) The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. Br J Pharmacol 157 55 PMID: 19413571

Tanaka et al (2016) Histamine H3 receptor antagonist OUP-186 attenuates the proliferation of cultured human breast cancer cell lines Biochemical and Biophysical Research Communication 480 479 PMID: 27773822

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