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Submit ReviewJNJ 27141491
说明： Potent and selective human CCR2 antagonist
化学名： 3-[(1S)-1-(3,4-Difluorophenyl)propyl]-2,3-dihydro-5-(5-isoxazolyl)-2-thioxo-1H-imidazole-4-carboxylic acid methyl ester
纯度： ≥98% (HPLC)
生物活性 for JNJ 27141491
Potent, noncompetitive human CCR2 antagonist; inhibits MCP-1-induced Ca2+ mobilization in hCCR2-CHO cells (IC50 = 13 nM). Exhibits selectivity for CCR2 over CCR1, CCR3-8 and CXCR1-3. Delays onset and reduces neurological signs in an experimental autoimmune encephalomyelitis model of multiple sclerosis in hCCR2 knock-in mice. Orally active.
技术数据 for JNJ 27141491
| 分子量 | 379.38 |
| 公式 | C17H15F2N3O3S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 871313-59-6 |
| PubChem ID | 11703589 |
| InChI Key | SYARXICKXVXWNA-LBPRGKRZSA-N |
| Smiles | FC1=CC([C@H](CC)N2C(C(OC)=O)=C(C3=CC=NO3)NC2=S)=CC=C1F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for JNJ 27141491
参考文献 for JNJ 27141491
参考文献是支持产品生物活性的出版物。
Buntinx et al (2008) Pharmacological profile of JNJ-27141491 [(S)-3-[3,4-difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl acid methyl ester], as a noncompetitive and orally active antagonist of the human chemokine receptor J.Pharmacol.Exp.Ther. 327 1 PMID: 18599682
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关键词: JNJ 27141491, JNJ 27141491 supplier, JNJ27141491, Chemokine, CC, Receptors, 5176, Tocris Bioscience
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