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JNJ 303

Cat. No. 3899 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective IKs blocker
化学名： 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for JNJ 303

JNJ 303 is a potent IKs blocker (IC50 = 64 nM). Displays no effects on other cardiac channels; IC50 values are 3.3, >10, 11.1 and 12.6 μM for INa, ICa, Ito and IKr currents respectively. Prolongs QT and causes unprovoked torsades de pointes (TdP).

许可信息

Sold with the permission of Janssen Pharmaceutica NV

技术数据 for JNJ 303

分子量 440.98
公式 C21H29ClN2O4S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 878489-28-2
PubChem ID 73016713
InChI Key OSGIRCJRKSAODN-UHFFFAOYSA-N
Smiles O=C(C(C)(C)OC4=CC=C(Cl)C=C4)NC2C1CC(CC2C3)CC3(NS(=O)(C)=O)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JNJ 303

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 11.02 25

制备储备液 for JNJ 303

以下数据基于产品分子量 440.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 9.07 mL 45.35 mL 90.71 mL
1.25 mM 1.81 mL 9.07 mL 18.14 mL
2.5 mM 0.91 mL 4.54 mL 9.07 mL
12.5 mM 0.18 mL 0.91 mL 1.81 mL

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产品说明书 for JNJ 303

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for JNJ 303

参考文献是支持产品生物活性的出版物。

Towart et al (2009) Blockade of the IKs potassium channel: an overlooked cardiovascular liability in drug safety screening? J.Pharm.Toxicol.Meth 60 1

If you know of a relevant reference for JNJ 303, please let us know.

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关键词: JNJ 303, JNJ 303 supplier, potent, Iks, blockers, JNJ303, potassium, K+, channels, selective, slow, delayed, rectifier, current, KCNQ1, Kv7.1, voltage-gated, voltage-dependent, Voltage-Gated, Potassium, Channels, 3899, Tocris Bioscience

2 篇 JNJ 303 的引用文献

引用文献是使用了 Tocris 产品的出版物。 JNJ 303 的部分引用包括：

Jens et al (2020) Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation. Elife 9 PMID: 33095155

Björk et al (2017) Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes. Front Physiol 8 884 PMID: 29163220

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