JNJ 39758979 dihydrochloride

Cat. No. 6279 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： High affinity and selective histamine H₄ antagonist; orally bioavailable

化学名： 4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for JNJ 39758979 dihydrochloride

JNJ 39758979 dihydrochloride is a high affinity and selective histamine H₄ antagonist (K_i = 12.5 nM). Exhibits >80-fold selectivity for H₄ over other histamine receptors and no significant activity at a range of other targets. Inhibits histamine-induced eosinophil shape change in whole blood in vitro and ovalbumin-induced inflammation in ovalbumin-sensitized mice in vivo. Orally bioavailable.

许可信息

Sold with the permission of Janssen Pharmaceutica N.V.

化合物库 for JNJ 39758979 dihydrochloride

JNJ 39758979 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for JNJ 39758979 dihydrochloride

分子量	294.22
公式	C₁₁H₁₉N₅.2HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
PubChem ID	129628806
InChI Key	KXPWYAVIFCXPRW-YCBDHFTFSA-N
Smiles	CC(C1=CC(N2CC[C@H](C2)N)=NC(N)=N1)C.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JNJ 39758979 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	22.13	100
	DMSO	22.13	100

制备储备液 for JNJ 39758979 dihydrochloride

以下数据基于产品分子量 294.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.4 mL	16.99 mL	33.99 mL
5 mM	0.68 mL	3.4 mL	6.8 mL
10 mM	0.34 mL	1.7 mL	3.4 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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产品说明书 for JNJ 39758979 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for JNJ 39758979 dihydrochloride

参考文献是支持产品生物活性的出版物。

Thurmond et al (2014) Clinical and preclinical characterization of the histamine H₄ receptor antagonist JNJ-39758979. J.Pharmacol.Exp.Ther. 349 176 PMID: 24549371

If you know of a relevant reference for JNJ 39758979 dihydrochloride, please let us know.

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关键词: JNJ 39758979 dihydrochloride, JNJ 39758979 dihydrochloride supplier, JNJ39758979, 2HCl, 1046447-90-8, high, affinity, selective, histamine, H4, antagonists, antagonism, anti-inflammatory, orally, bioavailable, Histamine, Receptors, 6279, Tocris Bioscience

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