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Submit ReviewJNJ 7777120
说明： Selective H4 antagonist
化学名： 1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine
纯度： ≥98% (HPLC)
生物活性 for JNJ 7777120
JNJ 7777120 is a histamine H4 receptor antagonist; displays high affinity (Ki = 4.5 nM) and is >1000-fold selective for H4 over other histamine receptors.
许可信息
Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.
化合物库 for JNJ 7777120
JNJ 7777120 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for JNJ 7777120
| 分子量 | 277.75 |
| 公式 | C14H16ClN3O |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 459168-41-3 |
| PubChem ID | 4908365 |
| InChI Key | HUQJRYMLJBBEDO-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(NC(C(N3CCN(C)CC3)=O)=C2)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for JNJ 7777120
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. HCl | 27.77 | 100 | |
| DMSO | 13.89 | 50 |
制备储备液 for JNJ 7777120
以下数据基于产品分子量 277.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.6 mL | 18 mL | 36 mL |
| 5 mM | 0.72 mL | 3.6 mL | 7.2 mL |
| 10 mM | 0.36 mL | 1.8 mL | 3.6 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
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产品说明书 for JNJ 7777120
参考文献 for JNJ 7777120
参考文献是支持产品生物活性的出版物。
Jablanowski et al (2003) The first potent and selective non-imidazole human histamine H4 receptor antagonists. J.Med.Chem. 46 3957 PMID: 12954048
Thurmond et al (2004) A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J.Pharmacol.Exp.Ther. 309 404 PMID: 14722321
Strakhova et al (2009) In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. Br.J.Pharmacol. 157 44 PMID: 19413570
If you know of a relevant reference for JNJ 7777120, please let us know.
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关键词: JNJ 7777120, JNJ 7777120 supplier, JNJ7777120, histamine, 4, histaminergic, H4, receptors, antagonists, selective, Histamine, Receptors, 4021, Tocris Bioscience
2 篇 JNJ 7777120 的引用文献
引用文献是使用了 Tocris 产品的出版物。 JNJ 7777120 的部分引用包括：
David et al (2020) Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth. Elife 9 PMID: 31931959
Fang et al (2019) Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch. Immunity 50 1163-1171.e5 PMID: 31027996
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.