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JNJ DGAT2-A

Cat. No. 5853 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： DGAT2 inhibitor
化学名： 3-Bromo-4-[2-fluoro-4-[[4-oxo-2-[[2-(pyridin-2-yl)ethyl]amino]-1,3-thiazol-5-(4H)ylidene]methyl]phenoxy]benzonitrile
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for JNJ DGAT2-A

JNJ DGAT2-A is a DGAT2 inhibitor (IC50 = 140 nM). Exhibits >70-fold selectivity for DGAT2 over DGAT1 and MGAT2.

技术数据 for JNJ DGAT2-A

分子量 523.38
公式 C24H16BrFN4O2S
储存 Store at +4°C
CAS Number 1962931-71-0
PubChem ID 101578741
InChI Key ZFRHAMOJHTZHLT-LPYMAVHISA-N
Smiles BrC1=C(OC2=C(F)C=C(/C=C3\SC(NCCC4=CC=CC=N4)=NC3=O)C=C2)C=CC(C#N)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JNJ DGAT2-A

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 52.34 100

制备储备液 for JNJ DGAT2-A

以下数据基于产品分子量 523.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.55 mL 19.11 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.96 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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参考文献 for JNJ DGAT2-A

参考文献是支持产品生物活性的出版物。

Qi et al (2012) The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2 J.Lipid Res. 53 1106 PMID: 22493088

Irshad et al (2017) Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytes. J.Lipid Res. 58 15 PMID: 27836993

If you know of a relevant reference for JNJ DGAT2-A, please let us know.

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关键词: JNJ DGAT2-A, JNJ DGAT2-A supplier, JNJDGAT2-A, Diacylglycerol, O-Acyltransferases, DGAT2, inhibitors, inhibits, DGAT-2iJ, O-Acyltransferase, 5853, Tocris Bioscience

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