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JPS036

Cat. No. 8085 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective HDAC3 Degrader (PROTAC®)
化学名： (2S,4R)-N-[2-[[12-[[4-[(2-Aminophenyl)carbamoyl]phenyl]amino]-12-oxododecyl]oxy]-4-(4-methylthiazol-5-yl)benzyl]-1-[(S)-2-(1-fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for JPS036

JPS036 is a selective HDAC3 Degrader (PROTAC®) (DC50 = 440 nM; Dmax = 77 %). JPS036 comprises a benzamide-based compound joined by a linker to a Von Hippel Lindau (VHL) E3 ligase ligand.

Negative control JPS016NC also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

许可信息

Sold under license from the University of Leicester

技术数据 for JPS036

分子量 940.19
公式 C51H66FN7O7S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2669785-85-5
PubChem ID 156808378
InChI Key NAADBQUVFJWCFU-XVYMMXEDSA-N
Smiles O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=C(C=C(C4=C(N=CS4)C)C=C3)OCCCCCCCCCCCC(NC5=CC=C(C=C5)C(NC6=C(C=CC=C6)N)=O)=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JPS036

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.8 20 温和加热

制备储备液 for JPS036

以下数据基于产品分子量 940.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 5.32 mL 26.59 mL 53.18 mL
1 mM 1.06 mL 5.32 mL 10.64 mL
2 mM 0.53 mL 2.66 mL 5.32 mL
10 mM 0.11 mL 0.53 mL 1.06 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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参考文献 for JPS036

参考文献是支持产品生物活性的出版物。

Smalley et al (2022) Optimization of class I histone deacetylase PROTACs reveals that HDAC1/2 degradation is critical to induce apoptosis and cell arrest in cancer cells. J.Med.Chem. 65 5642 PMID: 35293758

If you know of a relevant reference for JPS036, please let us know.

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关键词: JPS036, JPS036 supplier, JPS036, HDAC3, protac, degrader, degraders, degrades, selective, VHL, von, hippel, lindau, Protein, Degraders, PROTACs, proteolysis, targeting, chimera, active, Class, I, HDACs, Histone, Deacetylase, (HDAC), 8085, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Epigenetics in Cancer Research Product Guide

Epigenetics in Cancer Research Product Guide

This product guide reviews some of the main areas in cancer epigenetics research and lists around 120 products that can be used for the main epigenetic targets including:

  • Histone Methylation
  • Histone Acetylation
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  • Ubiquitination
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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia