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Submit ReviewJTE 907
说明： Selective CB2 receptor inverse agonist
化学名： N-(1,3-Benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-quinolinecarboxamide
纯度： ≥99% (HPLC)
生物活性 for JTE 907
JTE 907 is a highly selective cannabinoid CB2 receptor inverse agonist. Binds with high affinity to rat, mouse and human CB2 receptors (Ki values are 0.38, 1.55 and 35.9 nM respectively). Produces anti-inflammatory effects in vivo.
技术数据 for JTE 907
| 分子量 | 438.48 |
| 公式 | C24H26N2O6 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 282089-49-0 |
| PubChem ID | 9867770 |
| InChI Key | GRAJFFFXJYFVOC-UHFFFAOYSA-N |
| Smiles | CCCCCOC1=C2NC(=O)C(=CC2=CC=C1OC)C(=O)NCC1=CC2=C(OCO2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for JTE 907
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 43.85 | 100 | |
| ethanol | 4.38 | 10 |
制备储备液 for JTE 907
以下数据基于产品分子量 438.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.4 mL | 22.81 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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产品说明书 for JTE 907
参考文献 for JTE 907
参考文献是支持产品生物活性的出版物。
Iwamura et al (2001) In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. J.Pharmacol.Exp.Ther. 296 420 PMID: 11160626
Ueda et al (2005) Involvement of cannabinoid CB2 receptor-mediated response and efficacy of cannabinoid CB2 receptor inverse agonist, JTE 907, in cutaneous inflammation in mice. Eur.J.Pharmacol. 520 164 PMID: 16153638
Maekawa et al (2006) The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis. Eur.J.Pharmacol. 542 179 PMID: 16824511
If you know of a relevant reference for JTE 907, please let us know.
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关键词: JTE 907, JTE 907 supplier, Selective, CB2, receptor, antagonists, inverse, agonists, cannabinoids, Receptors, JTE907, cb2r, 2479, Tocris Bioscience
9 篇 JTE 907 的引用文献
引用文献是使用了 Tocris 产品的出版物。 JTE 907 的部分引用包括：
Kong et al (2016) Cannabinoid WIN-55,212-2 mesylate inhibits ADAMTS-4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan-1. Mol Cell Neurosci 13 4569 PMID: 27082728
Zhou et al (2015) Regional effects of endocannabinoid, BDNF and FGF receptor signalling on neuroblast motility and guidance along the rostral migratory stream. Br J Pharmacol 64 32 PMID: 25481343
Tan and Cao (2018) Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons. Int J Mol Med 42 919 PMID: 29786105
Sánchez-Blázquez et al (2013) Cannabinoid receptors couple to NMDA receptors to reduce the production of NO and the mobilization of zinc induced by glutamate. Antioxid Redox Signal 19 1766 PMID: 23600761
Marini et al (2013) Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors. Br J Pharmacol 169 887 PMID: 23711022
Vicente-Sánchez et al (2013) HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity. Mol Brain 6 42 PMID: 24093505
Price et al (2009) WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Eur J Neurosci 29 2177 PMID: 19490092
Wang et al (2016) Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest 126 4527 PMID: 27797339
Mair et al (2010) Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. Br J Pharmacol 161 176 PMID: 20718749
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JTE 907 的评论
平均评分: 5 (Based on 1 Review.)
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JTE 907 suppress skin inflammation.
By
Anonymous on 02/04/2020
分析类型： In Vivo
种属： Mouse
Orally administered JTE-907 (10 mg/kg) in a murine allergic contact dermatitis model.
Dissolved in DMSO
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.