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Submit ReviewJW 642
说明： MAGL inhibitor
化学名： 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
纯度： ≥98% (HPLC)
生物活性 for JW 642
JW 642 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC50 = 3.7 nM). Displays >1000-fold selectivity for MAGL over fatty acid amide hydrolase (IC50 = 20.6 μM). Analog of JZL 195 (Cat. No. 4715).
许可信息
Sold under license from The Scripps Research Institute
技术数据 for JW 642
| 分子量 | 462.39 |
| 公式 | C21H20F6N2O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1416133-89-5 |
| PubChem ID | 71656520 |
| InChI Key | AVSCNEOUWSVZEY-UHFFFAOYSA-N |
| Smiles | O=C(OC(C(F)(F)F)C(F)(F)F)N(CC3)CCN3CC1=CC(OC2=CC=CC=C2)=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for JW 642
参考文献 for JW 642
参考文献是支持产品生物活性的出版物。
Chang et al (2012) Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem.Biol. 19 579 PMID: 22542104
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关键词: JW 642, JW 642 supplier, JW642, MAGL, monoacylglycerol, potent, selective, inhibitors, inhibits, lipases, esterases, 4906, Tocris Bioscience
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