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Submit ReviewJWH 015
说明： Selective CB2 agonist
化学名： (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone
纯度： ≥99% (HPLC)
生物活性 for JWH 015
Selective CB2 agonist (Ki values are 13.8 and 383 nM as measured at human cloned CB2 and CB1 receptors expressed in CHO cells).
技术数据 for JWH 015
| 分子量 | 327.43 |
| 公式 | C23H21NO |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 155471-08-2 |
| PubChem ID | 4273754 |
| InChI Key | LJSBBBWQTLXQEN-UHFFFAOYSA-N |
| Smiles | CCCN1C(C)=C(C(=O)C2=CC=CC3=CC=CC=C23)C2=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for JWH 015
参考文献 for JWH 015
参考文献是支持产品生物活性的出版物。
Chin et al (1999) The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor. J.Pharmacol.Exp.Ther. 291 837 PMID: 10525107
Griffin et al (1997) Evidence for the presence of CB2-like receptor on peripheral nerve terminals. Eur.J.Pharmacol. 339 53 PMID: 9450616
Pertwee et al (1999) Pharmacology of cannabinoid receptor ligands. Curr.Med.Chem. 6 635 PMID: 10469884
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关键词: JWH 015, JWH 015 supplier, Selective, CB2, agonists, Cannabinoids, Receptors, JWH015, cb2r, 1341, Tocris Bioscience
21 篇 JWH 015 的引用文献
引用文献是使用了 Tocris 产品的出版物。 JWH 015 的部分引用包括：
Fechtner et al (2019) Cannabinoid Receptor 2 Agonist JWH-015 Inhibits Interleukin-1β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts and in Adjuvant Induced Arthritis Rat via Glucocorticoid Receptor. Front Immunol 10 1027 PMID: 31139184
Robinson et al (2013) Cannabinoids inhibit T-cells via cannabinoid receptor 2 in an in vitro assay for graft rejection, the mixed lymphocyte reaction. J Neuroimmune Pharmacol 8 1239 PMID: 23824763
Hervera et al (2010) The role of nitric oxide in the local antiallodynic and antihyperalgesic effects and expression of delta-opioid and cannabinoid-2 receptors during neuropathic pain in mice. J Pharmacol Exp Ther 334 887 PMID: 20498253
Hanlon et al (2016) Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent. Breast Cancer (Dove Med Press) 8 59 PMID: 27186076
Ghosh et al (2018) The Endocannabinoid/Cannabinoid Receptor 2 System Protects Against Cisplatin-Induced Hearing Loss. Front Cell Neurosci 12 271 PMID: 30186120
Agudelo et al (2016) Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol 6 1452 PMID: 26733986
Verty et al (2015) Anti-Obesity Effect of the CB2 Receptor Agonist JWH-015 in Diet-Induced Obese Mice. PLoS One 10 e0140592 PMID: 26588700
Preet et al (2011) Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis. Cancer Prev Res (Phila) 4 65 PMID: 21097714
DiPatrizio et al (2011) Endocannabinoid signal in the gut controls dietary fat intake. Proc Natl Acad Sci U S A 108 12904 PMID: 21730161
Negrete et al (2011) The antinociceptive effects of JWH-015 in chronic inflammatory pain are produced by nitric oxide-cGMP-PKG-KATP pathway activation mediated by opioids. PLoS One 6 e26688 PMID: 22031841
McGuinness et al (2009) Characterizing cannabinoid CB2 receptor ligands using DiscoveRx PathHunter β-arrestin assay. Mol Pharmacol 14 49 PMID: 19171920
Sheng et al (2019) Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain. Pain Res Manag 2019 1260353 PMID: 31354896
Landry et al (2012) Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain. J Pain 13 836 PMID: 22901764
Price et al (2009) WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Eur J Neurosci 29 2177 PMID: 19490092
Small-Howard et al (2005) Anti-inflammatory potential of CB1-mediated cAMP elevation in mast cells. Biochem J 388 465 PMID: 15669919
Börner et al (2006) Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells. Mol Cell Neurosci 69 1486 PMID: 16434616
Jiang et al Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. PLoS One 2 e641 PMID: 17653268
Lépicier et al (2003) Endocannabinoids protect the rat isolated heart against ischaemia. Br J Pharmacol 139 805 PMID: 12813004
McKallip et al (2002) Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease. Blood 100 627 PMID: 12091357
Ford et al (2002) Evidence of a novel site mediating anandamide-induced negative inotropic and coronary vasodilatator responses in rat isolated hearts. Br J Pharmacol 135 1191 PMID: 11877326
Ehrhart et al (2005) Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J Neuroinflammation 2 29 PMID: 16343349
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breast cancer cell viability by a cannabinoid receptor 2 agonist.
By
Anonymous on 03/15/2020
分析类型： In Vitro
种属： Human
细胞系/组织： MCF-7
We used all these compounds which were dissolved in DMSO and added to fresh culture media. Concentration reference paper PMID: 27186076
该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.