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Submit ReviewJX 401
说明： Potent, reversible p38α inhibitor
化学名： 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine
纯度： ≥98% (HPLC)
生物活性 for JX 401
JX 401 is a potent, reversible inhibitor of p38α that displays no activity on the p38γ isoform (IC50 values are 32 nM and > 10 μM respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.
化合物库 for JX 401
JX 401 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for JX 401
| 分子量 | 355.49 |
| 公式 | C21H25NO2S |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 349087-34-9 |
| PubChem ID | 1126109 |
| InChI Key | OMGLGPKQUFSRNN-UHFFFAOYSA-N |
| Smiles | COC1=C(C=CC(SC)=C1)C(=O)N1CCC(CC2=CC=CC=C2)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for JX 401
参考文献 for JX 401
参考文献是支持产品生物活性的出版物。
Friedmann et al (2006) JX401, a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast. Mol.Pharmacol. 70 1395 PMID: 16847144
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关键词: JX 401, JX 401 supplier, Potent, reversible, p38α, p38alpha, inhibitors, inhibits, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, JX401, p38, 2657, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for JX 401
