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JZP 430

Cat. No. 5844 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
化学名： 4-(4-Morpholinyl)-1,2,5-thiadiazol-3-yl N-cyclooctyl-N-methylcarbamate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for JZP 430

JZP 430 is a potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 44 nM). Exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).

化合物库 for JZP 430

JZP 430 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for JZP 430

分子量 354.47
公式 C16H26N4O3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1672691-74-5
PubChem ID 121513897
InChI Key WKSHMJCYWFOADB-UHFFFAOYSA-N
Smiles O=C(N(C)C1CCCCCCC1)OC2=NSN=C2N3CCOCC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JZP 430

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.72 50
ethanol 7.09 20

制备储备液 for JZP 430

以下数据基于产品分子量 354.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.64 mL 28.21 mL 56.42 mL
2.5 mM 1.13 mL 5.64 mL 11.28 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
25 mM 0.11 mL 0.56 mL 1.13 mL

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参考文献 for JZP 430

参考文献是支持产品生物活性的出版物。

Patel et al (2015) Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. Chem.Med.Chem. 10 253 PMID: 25504894

If you know of a relevant reference for JZP 430, please let us know.

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