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Submit ReviewKartogenin
说明： Potently induces chondrogenesis in MSCs
化学名： 2-[((1,1'-Biphenyl)-4-ylamino)carbonyl]benzoic acid
纯度： ≥98% (HPLC)
生物活性 for Kartogenin
Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Reduces disease severity in a mouse model of osteoarthritis; displays protective effects against osteoarthritic stimuli in mature chondrocytes in vitro.
化合物库 for Kartogenin
Kartogenin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Kartogenin
| 分子量 | 317.34 |
| 公式 | C20H15NO3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 4727-31-5 |
| PubChem ID | 2826191 |
| InChI Key | SLUINPGXGFUMLL-UHFFFAOYSA-N |
| Smiles | O=C(NC2=CC=C(C3=CC=CC=C3)C=C2)C1=CC=CC=C1C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Kartogenin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 31.73 | 100 | |
| ethanol | 15.87 | 50 |
制备储备液 for Kartogenin
以下数据基于产品分子量 317.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.15 mL | 15.76 mL | 31.51 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.3 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.15 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
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产品说明书 for Kartogenin
参考文献 for Kartogenin
参考文献是支持产品生物活性的出版物。
Johnson et al (2012) A stem cell-based approach to cartilage repair. Science 336 717 PMID: 22491093
If you know of a relevant reference for Kartogenin, please let us know.
关键词: Kartogenin, Kartogenin supplier, Supplier, mesenchymal, stem, cell, differentiation, differentiators, potently, inducers, chondrocytes, cartilage, osteoarthritis, Mesenchymal, Stem, Cells, 4513, Tocris Bioscience
篇 Kartogenin 的引用文献
引用文献是使用了 Tocris 产品的出版物。
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Kartogenin 的评论
平均评分: 5 (Based on 1 Review.)
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Chondrogenic differentiation of human bone marrow stromal cells.
By
Nicola Foster on 08/28/2020
分析类型： In Vitro
种属： Human
Added to culture medium on days 1-3 at 10 µM to induced chondrogenic differentiation in an immortalized hBMSC cell line. After 7 days there was increased sulfated GAG production compared to basic controls and increased DNA yield compared to cells cultured in traditional chondrogenic differentiation medium.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.