KC 12291 hydrochloride

Name: KC 12291 hydrochloride
Brand: Tocris Bioscience
SKU: 3251

Cat. No. 3251 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3251 has been discontinued.

View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.

说明： Orally active atypical Na⁺ channel blocker; cardioprotective

化学名： 3,4-Dimethoxy-N-methyl-N-[3-[(5-phenyl-1,2,4-thiadiazol-3-yl)oxy]propyl]benzeneethanamine hydrochloride

纯度： ≥97% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for KC 12291 hydrochloride

KC 12291 hydrochloride is an orally active atypical voltage-gated sodium channel blocker. Inhibits sustained sodium currents (I_NaL) and prevents diastolic contracture in isolated atria in vitro (IC₅₀ values are 9.6 and 0.55 - 0.79 μM respectively). Displays anti-ischemic, bradycardic and cardioprotective activity in vivo.

技术数据 for KC 12291 hydrochloride

分子量	449.99
公式	C₂₂H₂₇N₃O₃S.HCl
储存	Desiccate at +4°C
纯度	≥97% (HPLC)
CAS Number	181936-98-1
PubChem ID	22902387
InChI Key	KIJPRQYBNQKUAU-UHFFFAOYSA-N
Smiles	CN(CCCOC2=NSC(C3=CC=CC=C3)=N2)CCC1=CC=C(OC)C(OC)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for KC 12291 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for KC 12291 hydrochloride

参考文献是支持产品生物活性的出版物。

Tamareille et al (2002) Anti-ischemic compound KC 12291 prevents diastolic contracture in isolated atria by blockade of voltage-gated sodium channels. J.Cardiovasc.Pharmacol. 40 346 PMID: 12198320

John et al (2004) KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties. Cardiovasc.Drug Rev. 22 17 PMID: 14978516

Letienne et al (2006) Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart. Eur.J.Pharmacol. 530 243 PMID: 16368090

Decking et al (1998) Cardioprotective actions of KC 12291. Naunyn-Schmied.Arch.Pharmacol. 358 547

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篇 KC 12291 hydrochloride 的引用文献

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目前没有 KC 12291 hydrochloride 的引用文献。