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Submit ReviewKCC 07
说明： MBD2 (Methyl-CpG-binding domain protein 2) inhibitor
化学名： 3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol
纯度： ≥98% (HPLC)
生物活性 for KCC 07
KCC 07 is a MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.
技术数据 for KCC 07
| 分子量 | 269.32 |
| 公式 | C14H11N3OS |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 315702-75-1 |
| PubChem ID | 704347 |
| InChI Key | GIGNWEDIMLUWCT-UHFFFAOYSA-N |
| Smiles | OC1=CC=CC(NC2=NC(C3=CC=CC=N3)=CS2)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for KCC 07
参考文献 for KCC 07
参考文献是支持产品生物活性的出版物。
Zhu et al (2018) BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 33 1004 PMID: 29894688
关键词: KCC 07, KCC 07 supplier, KCC07, MBD2, inhibitors, inhibits, Methyl-CpG-binding, domain, protein, 2, medulloblastoma, BAI1, p53, signaling, activators, activates, DNA, Methyltransferases, 6615, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Epigenetics in Cancer Research Product Guide
This product guide reviews some of the main areas in cancer epigenetics research and lists around 120 products that can be used for the main epigenetic targets including:
- Histone Methylation
- Histone Acetylation
- DNA Methylation
- Ubiquitination
- Bromodomains
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.