Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewKH 7
说明： Selective soluble adenylyl cyclase inhibitor
化学名： (±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide
纯度： ≥99% (HPLC)
生物活性 for KH 7
KH 7 is a selective soluble adenylyl cyclase (sAC) inhibitor (IC50 = 3 - 10 μM in vivo). Inert towards transmembrane adenylyl cyclase (tmAC) in vitro and in whole cells at concentrations up to 300 μM. Blocks synthesis of cAMP and displays an antiapoptotic effect at concentrations of 1 - 100 μM.
技术数据 for KH 7
| 分子量 | 419.3 |
| 公式 | C17H15BrN4O2S |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 330676-02-3 |
| PubChem ID | 6843191 |
| InChI Key | GEHVZUUHMWNMAY-UHFFFAOYSA-N |
| Smiles | OC(C=CC(Br)=C2)=C2/C=N/NC(C(C)SC1=NC(C=CC=C3)=C3N1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for KH 7
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 41.93 | 100 |
制备储备液 for KH 7
以下数据基于产品分子量 419.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.92 mL | 23.85 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.77 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for KH 7
参考文献 for KH 7
参考文献是支持产品生物活性的出版物。
Kumar et al (2009) Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. J.Biol.Chem. 284 14760 PMID: 19336406
Stessin et al (2006) Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J.Biol.Chem. 281 17253 PMID: 16627466
Hess et al (2005) The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Develop.Cell 9 249
If you know of a relevant reference for KH 7, please let us know.
按产品操作查看相关产品
关键词: KH 7, KH 7 supplier, selective, adenylyl, cyclases, inhibitors, inhibits, soluble, sAC, KH7, Adenylyl, Cyclase, 3834, Tocris Bioscience
9 篇 KH 7 的引用文献
引用文献是使用了 Tocris 产品的出版物。 KH 7 的部分引用包括：
Shahidullah et al (2014) Nonpigmented ciliary epithelial cells respond to acetazol. by a soluble adenylyl cyclase mechanism. Invest Ophthalmol Vis Sci 55 187 PMID: 24282227
Jahchan et al (2013) A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov 3 1364 PMID: 24078773
Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333
Yamada et al (2018) Reconsideration of the evaluation criteria for bull ejaculated sperm motility in the context of rotation. J Reprod Dev 64 377 PMID: 29952339
Chen et al (2013) Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway. Mediators Inflamm 9 2033 PMID: 24145604
Ishii et al (2019) An improved method for isolation of mitochondria from cell lines that enables reconstitution of calcium-dependent processes. Anal Biochem 577 52 PMID: 31022379
Schnúr et al (2019) Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia. Sci Rep 9 12706 PMID: 31481727
Inda et al (2017) cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells. Sci Rep 7 1944 PMID: 28512295
Inda et al (2016) Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling. J Cell Biol 214 181 PMID: 27402953
您是否知道使用了 Tocris KH 7 的优秀论文？ 请告知我们.
KH 7 的评论
平均评分: 5 (Based on 1 Review.)
Have you used KH 7?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
a selective sAC inhibitor.
By
Hyun Choi on 01/31/2018
分析类型： Ex Vivo
种属： Rat
Used KH7 to block soluble adenylyl cyclase which is sensitive to bicarbonate. Used at 20uM in rat brain slice.
pretreat KH7 at least 30 min before treatment