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Submit ReviewKHS 101 hydrochloride
说明： Selective inducer of neuronal differentiation in hippocampal neural progenitors
化学名： N4-(2-Methylpropyl)-N2-[(2-phenyl-4-thiazolyl)methyl]-2,4-pyrimidinediamine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for KHS 101 hydrochloride
KHS 101 hydrochloride is a selective inducer of neuronal differentiation; induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50 ~1 μM). Suppresses astrocyte formation. Also induces acceleration of neuronal differentiation in the hippocampal dentate gyrus in vivo.
化合物库 for KHS 101 hydrochloride
KHS 101 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for KHS 101 hydrochloride
| 分子量 | 375.92 |
| 公式 | C18H21N5S.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1784282-12-7 |
| PubChem ID | 90488983 |
| InChI Key | INVQHPQJFRKGIO-UHFFFAOYSA-N |
| Smiles | CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for KHS 101 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 18.8 | 50 | |
| ethanol | 18.8 | 50 |
制备储备液 for KHS 101 hydrochloride
以下数据基于产品分子量 375.92。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.32 mL | 26.6 mL | 53.2 mL |
| 2.5 mM | 1.06 mL | 5.32 mL | 10.64 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.32 mL |
| 25 mM | 0.11 mL | 0.53 mL | 1.06 mL |
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产品说明书 for KHS 101 hydrochloride
参考文献 for KHS 101 hydrochloride
参考文献是支持产品生物活性的出版物。
Wurdak et al (2010) A small molecule accelerates neuronal differentiation in the adult rat. Proc.Natl.Acad.Sci.USA. 107 16542 PMID: 20823227
If you know of a relevant reference for KHS 101 hydrochloride, please let us know.
关键词: KHS 101 hydrochloride, KHS 101 hydrochloride supplier, KHS101, hydrochloride, transforming, acidic, coiled-coil-containing, protein, 3, TACC3, NPC, hippocampal, neural, progenitors, cells, neuronal, differentiation, maturing, neurons, differentiated, selective, activators, [1262770-73-9], Neural, Stem, Cells, 4888, Tocris Bioscience
1 篇 KHS 101 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 KHS 101 hydrochloride 的部分引用包括：
Henrik Daa et al (2021) Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting. J Exp Clin Cancer Res 40 248 PMID: 34364401
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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