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KI-7

Cat. No. 6787 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Positive allosteric modulator of A2B receptors
化学名： α-Oxo-N-phenyl-1-(phenylmethyl)-1H-indole-3-acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for KI-7

KI-7 is an adenosine A2B receptor positive allosteric modulator. Potentiates the NECA (Cat. No. 1691) -induced increase in cAMP production in CHO cells expressing A2B receptors. Also potentiates the effects of NECA and the A2B receptor agonist BAY 60-6583 (Cat. No. 4472) in mediating osteoblast differentiation from MSCs in vitro.

化合物库 for KI-7

KI-7 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for KI-7

分子量 354.4
公式 C23H18N2O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1489263-00-4
PubChem ID 73350966
InChI Key MQMGZFRIEZRHHJ-UHFFFAOYSA-N
Smiles O=C(C(C1=CN(C2=CC=CC=C12)CC3=CC=CC=C3)=O)NC4=CC=CC=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for KI-7

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 17.72 50

制备储备液 for KI-7

以下数据基于产品分子量 354.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.64 mL 28.22 mL 56.43 mL
2.5 mM 1.13 mL 5.64 mL 11.29 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
25 mM 0.11 mL 0.56 mL 1.13 mL

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参考文献 for KI-7

参考文献是支持产品生物活性的出版物。

Trincavelli et al (2014) Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim.Biophys.Acta 1843 2957 PMID: 25241343

Trincavelli et al (2014) Allosteric modulators of human A2B adenosine receptor. Biochim.Biophys.Acta 1840 1194 PMID: 24361612

If you know of a relevant reference for KI-7, please let us know.

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关键词: KI-7, KI-7 supplier, adenosine, A2B, receptor, positive, allosteric, modulators, PAMs, modulates, mesenchymal, stem, cells, MSCs, osteoblast, differentiation, Adenosine, Receptors, Mesenchymal, Stem, Cells, 6787, Tocris Bioscience

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