Kisspeptin 10 (human)

Cat. No. 2570 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Endogenous ligand for kisspeptin receptor

别名： Metastin (45-54),Kp-10

纯度： ≥95% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Kisspeptin 10 (human)

Kisspeptin 10 (human) is a potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with K_i values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration.

Analog also available.

技术数据 for Kisspeptin 10 (human)

分子量	1302.45
公式	C₆₃H₈₃N₁₇O₁₄
序列	YNWNSFGLRF (Modification: Phe-10 = C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	374675-21-5
PubChem ID	25240297
InChI Key	RITKWYDZSSQNJI-INXYWQKQSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Kisspeptin 10 (human)

溶解性	Soluble to 1 mg/ml in water

产品说明书 for Kisspeptin 10 (human)

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Kisspeptin 10 (human)

参考文献是支持产品生物活性的出版物。

Kotani et al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 276 34631 PMID: 11457843

Peilecka-Fortuna et al (2007) Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by OE. Endocrinology 149 1979 PMID: 18162521

Becker et al (2005) Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other G_q-coupled receptors. Biochem.Biophys.Res.Comm. 326 677

If you know of a relevant reference for Kisspeptin 10 (human), please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Kisspeptin Receptor Agonists

关键词: Kisspeptin 10 (human), Kisspeptin 10 (human) supplier, Endogenous, ligands, KISS1, receptors, hOT7T175/AXOR12/GPR54, Metastin, KISS-derived, Peptide, Kisspeptin10, (45-54), Kp-10, Kisspeptin, Receptor, 2570, Tocris Bioscience