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Submit ReviewKlotho-derived peptide 1
说明： TGF-β receptor 2 (TβR2) binding peptide; disrupts the TGF-β/TβR2 interaction
纯度： ≥95% (HPLC)
生物活性 for Klotho-derived peptide 1
Klotho-derived peptide 1 (KP1) is a peptide that binds to TGF-β receptor 2 (TβR2) (Kd = 1.4 μM). It inhibits TGF-β signaling by blocking TGF-β/TβR2 interaction. In mouse models of renal fibrosis, intravenous injection of KP1 results in its specific accumulation in the injured kidneys. It suppresses TGF-β signaling, repressing fibroblast activation and ameliorates kidney fibrosis in vivo.
技术数据 for Klotho-derived peptide 1
| 分子量 | 3228.48 |
| 公式 | C149H203N39O43 |
| 序列 | FQGTFPDGFLWAVGSAAYQTEGGWQQHGKG |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| InChI Key | UYTUWBDQBGRXJP-SOZMHADISA-N |
| Smiles | O=C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(C)C)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](C)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(NCC(NCC(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC9=CNC=N9)C(NCC(N[C@@H](CCCCN)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC%10=CC=CC=C%10)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Klotho-derived peptide 1
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for Klotho-derived peptide 1
参考文献 for Klotho-derived peptide 1
参考文献是支持产品生物活性的出版物。
Yuan et al (2022) A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling. Nat.Commun. 13 438 PMID: 35064106
If you know of a relevant reference for Klotho-derived peptide 1, please let us know.
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关键词: Klotho-derived peptide 1, Klotho-derived peptide 1 supplier, TGF-βRII, TGF-β, TGF-betaRII, TGFbRII, TGFbR2, Kinases, Transforming, Growth, Factors, Beta, Receptors, TGF-beta, RSTK, Receptor, Serine/Threonine, RSTKs, KP1, renal, fibrosis, kidney, in, vivo, 7830, Tocris Bioscience
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for Klotho-derived peptide 1
