Klotho-derived peptide 6

Cat. No. 7847 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Wnt/β-catenin signaling inhibitor

纯度： ≥95% (HPLC)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Klotho-derived peptide 6

Klotho-derived peptide 6 is a β-catenin signaling inhibitor. Binds to and sequesters Wnt ligands in vitro; prevents expression of Wnt1-induced fibronectin and α-smooth muscle action. In an in vivo mouse model of diabetic kidney disease, Klotho-derived peptide 6 reduces kidney injury, improves survival and prevents accumulation of fibronectin and collagen IV in glomeruli.

技术数据 for Klotho-derived peptide 6

分子量	3491.87
公式	C₁₅₉H₂₃₂N₄₆O₄₄
序列	QPVVTLYHWDLPQRLQDAYGGWANRALADH
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	2102414-23-1
InChI Key	BQDMNXDIAPCSQW-XCQHBGKYSA-N
Smiles	O=C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N6[C@@H](CCC6)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@@H](CC7=CC=C(C=C7)O)C(NCC(NCC(N[C@@H](CC8=CNC9=CC=CC=C89)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC%10=CNC=N%10)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(N)=O)N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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溶解性数据 for Klotho-derived peptide 6

溶解性	Soluble to 1 mg/ml in water

产品说明书 for Klotho-derived peptide 6

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Klotho-derived peptide 6

参考文献是支持产品生物活性的出版物。

Chen et al (2022) Klotho-derived peptide 6 ameliorates diabetic kidney disease by targeting Wnt/β-catenin signaling. Kidney Int. 102 506 PMID: 35644285

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