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说明： HSF1 inhibitor
化学名： N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine
纯度： ≥99% (HPLC)
生物活性 for KRIBB11
KRIBB11 is a heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). Increases apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin (Cat. No. 1368) and 17-AAG (Cat. No. 1515). Blocks downstream induction of HSP27 and HSP70. Inhibits tumor growth in vivo.
技术数据 for KRIBB11
| 分子量 | 284.27 |
| 公式 | C13H12N6O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 342639-96-7 |
| PubChem ID | 69894253 |
| InChI Key | NDJJEQIMIJJCLL-UHFFFAOYSA-N |
| Smiles | CNC1=NC(NC2=CC=C(NN=C3)C3=C2)=C([N+]([O-])=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for KRIBB11
参考文献 for KRIBB11
参考文献是支持产品生物活性的出版物。
Yoon et al (2011) KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J.Biol.Chem. 286 1737 PMID: 21078672
Samarasinghe et al (2014) Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem. Pharmacol. 87 445 PMID: 24291777
关键词: KRIBB11, KRIBB11 supplier, HSF1, inhibitors, inhibits, heat, shock, factors, 1, HSP90, HSP70, HSP27, proteins, Hsp90, Hsp70, Other, Transcription, Factors, 5480, Tocris Bioscience
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该领域的文献
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
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