KRIBB11

Cat. No. 5480 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： HSF1 inhibitor

化学名： N²-1H-Indazol-5-yl-N⁶-methyl-3-nitro-2,6-pyridinediamine

纯度： ≥99% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for KRIBB11

KRIBB11 is a heat shock factor (HSF) inhibitor (IC₅₀ = 1.2 μM). Increases apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin (Cat. No. 1368) and 17-AAG (Cat. No. 1515). Blocks downstream induction of HSP27 and HSP70. Inhibits tumor growth in vivo.

技术数据 for KRIBB11

分子量	284.27
公式	C₁₃H₁₂N₆O₂
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	342639-96-7
PubChem ID	69894253
InChI Key	NDJJEQIMIJJCLL-UHFFFAOYSA-N
Smiles	CNC1=NC(NC2=CC=C(NN=C3)C3=C2)=C([N+]([O-])=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for KRIBB11

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	28.43	100

制备储备液 for KRIBB11

以下数据基于产品分子量 284.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.52 mL	17.59 mL	35.18 mL
5 mM	0.7 mL	3.52 mL	7.04 mL
10 mM	0.35 mL	1.76 mL	3.52 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

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产品说明书 for KRIBB11

分析证书/产品说明书

化学品安全技术说明书

参考文献 for KRIBB11

参考文献是支持产品生物活性的出版物。

Yoon et al (2011) KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J.Biol.Chem. 286 1737 PMID: 21078672

Samarasinghe et al (2014) Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem. Pharmacol. 87 445 PMID: 24291777

If you know of a relevant reference for KRIBB11, please let us know.

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关键词: KRIBB11, KRIBB11 supplier, HSF1, inhibitors, inhibits, heat, shock, factors, 1, HSP90, HSP70, HSP27, proteins, Hsp90, Hsp70, Other, Transcription, Factors, 5480, Tocris Bioscience

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