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KYA 1797K

Cat. No. 7002 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Wnt/β-catenin signaling inhibitor
化学名： (5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for KYA 1797K

KYA 1797K is a Wnt/β-catenin signaling inhibitor (IC50 = 0.75 μM). Increases binding affinity of β-catenin for axin, GSK-3β and β-TrCP. Promotes formation of the destruction complex, activation of GSK-3β and phosphorylation of β-catenin and K-Ras, leading to their degradation via the ubiquitin/proteasome system. Reduces levels of β-catenin and K-Ras and inhibits growth of colorectal cancer (CRC) cells in vitro and in mouse xenograft models.

技术数据 for KYA 1797K

分子量 442.5
公式 C17H11KN2O6S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1956356-56-1
PubChem ID 119057297
InChI Key PHUNRLYHXGMOLG-WQRRWHLMSA-M
Smiles C1=CC(=CC=C1C2=CC=C(O2)/C=C\3/C(=O)N(C(=S)S3)CCC(=O)[O-])[N+](=O)[O-].[K+]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for KYA 1797K

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 2.21 5 温和加热

制备储备液 for KYA 1797K

以下数据基于产品分子量 442.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 45.2 mL 225.99 mL 451.98 mL
0.25 mM 9.04 mL 45.2 mL 90.4 mL
0.5 mM 4.52 mL 22.6 mL 45.2 mL
2.5 mM 0.9 mL 4.52 mL 9.04 mL

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参考文献 for KYA 1797K

参考文献是支持产品生物活性的出版物。

Cha et al (2016) Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat.Chem.Biol. 12 593 PMID: 27294323

Park et al (2019) A Ras destabilizer KYA1797K overcomes the resistance of EGFR tyrosine kinase inhibitor in KRAS-mutated non-small cell lung cancer. Sci.Rep. 9 648 PMID: 30679620

If you know of a relevant reference for KYA 1797K, please let us know.

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关键词: KYA 1797K, KYA 1797K supplier, KYA1797K, wnt, beta, catenin, β, signaling, pathway, inhibitors, inhibits, K-Ras, destruction, complex, promotes, Beta-catenin, 7002, Tocris Bioscience

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Pathways for KYA 1797K

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.