Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewKYL
说明： EphA4 kinase inhibitor; neuroprotective
纯度： ≥95% (HPLC)
生物活性 for KYL
KYL is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively). Neuroprotective.
技术数据 for KYL
| 分子量 | 1465.75 |
| 公式 | C74H108N14O17 |
| 序列 | KYLPYWPVLSSL |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 676657-00-4 |
| PubChem ID | 91691122 |
| InChI Key | FZNPYIAZMDBRLC-RKNDTPCJSA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for KYL
| 溶解性 | Soluble to 2 mg/ml in water |
产品说明书 for KYL
参考文献 for KYL
参考文献是支持产品生物活性的出版物。
Lamberto et al (2012) Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem. J. 445 47 PMID: 22489865
Vargas et al (2014) EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. PLoS One. 9 e92309 PMID: 24658113
If you know of a relevant reference for KYL, please let us know.
按产品操作查看相关产品
关键词: KYL, KYL supplier, Ephrins, EphA4, receptor, tyrosine, kinase, antagonists, promotes, axon, regeneration, long, term, potentiation, Eph, Receptors, 5290, Tocris Bioscience
1 篇 KYL 的引用文献
引用文献是使用了 Tocris 产品的出版物。 KYL 的部分引用包括：
Defourny et al (2019) EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions. iScience 11 246 PMID: 30639848
您是否知道使用了 Tocris KYL 的优秀论文？ 请告知我们.
KYL 的评论
目前没有该产品的评论。 Be the first to review KYL and earn rewards!
Have you used KYL?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.