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Submit ReviewKynurenic acid sodium salt is a sodium salt of kynurenic acid (Cat. No. 0223), a broad spectrum EAA antagonist.
Kynurenic acid sodium salt is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
分子量 | 211.15 |
公式 | C10H6NNaO3 |
储存 | Desiccate at RT |
纯度 | ≥98% (HPLC) |
CAS Number | 2439-02-3 |
PubChem ID | 52974250 |
InChI Key | RCAZGXKUQDXSSK-UHFFFAOYSA-M |
Smiles | [Na+].OC1=CC(=NC2=CC=CC=C12)C([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 21.11 | 100 | |
DMSO | 10.56 | 50 |
以下数据基于产品分子量 211.15。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 4.74 mL | 23.68 mL | 47.36 mL |
5 mM | 0.95 mL | 4.74 mL | 9.47 mL |
10 mM | 0.47 mL | 2.37 mL | 4.74 mL |
50 mM | 0.09 mL | 0.47 mL | 0.95 mL |
参考文献是支持产品生物活性的出版物。
Perkins and Stone (1982) An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res. 247 184 PMID: 6215086
Pittaluga et al (1997) The 'kynurenate test', a biochemical assay for putative cognition enhancers. J.Pharmacol.Exp.Ther. 283 82 PMID: 9336311
Wang et al (2006) Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J.Biol.Chem. 281 22021 PMID: 16754668
Stone and Burton (1988) NMDA receptors and ligands in the vertebrate CNS. Progr.Neurobiol. 30 333 PMID: 2830636
If you know of a relevant reference for Kynurenic acid sodium salt, please let us know.
关键词: Kynurenic acid sodium salt, Kynurenic acid sodium salt supplier, Broad, spectrum, EAA, antagonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Non-selective, GPR35, 3694, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Kynurenic acid sodium salt 的部分引用包括:
Ruilong et al (2021) Long-Range GABAergic Inhibition Modulates Spatiotemporal Dynamics of the Output Neurons in the Olfactory Bulb. J Neurosci 41 3610-3621 PMID: 33687961
Stefano et al (2022) Brainstem activation of GABAB receptors in the nucleus tractus solitarius increases gastric motility. Front Neurosci 16 961042 PMID: 35983226
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.