L-364,373

Name: L-364,373
Brand: Tocris Bioscience
SKU: 2660
Rating: 5 (1 reviews)

Cat. No. 2660 4 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2660 has been discontinued.

View all Voltage-gated Potassium (K<sub>V</sub>) Channels products.

说明： K_V7.1 channel activator, activates I_Ks

别名： R-L3

化学名： 5-(2-Fluorophenyl)-1,3-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-2H-1,4-benzodiazepin-2-one

纯度： ≥98% (HPLC)

说明书

引用文献 (4)

生物活性技术数据说明书参考文献

生物活性 for L-364,373

L-364,373 is an activator of K_V7.1 (KCNQ1) channels. Activates the cardiac I_Ks current that decreases action potential duration (APD) in cardiac myocytes.

技术数据 for L-364,373

分子量	397.44
公式	C₂₅H₂₀FN₃O
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	103342-82-1
PubChem ID	656755
InChI Key	CGBANSGENFERAT-JOCHJYFZSA-N
Smiles	CN(C1=CC=CC=C1C(C5=CC=CC=C5F)=N[C@@H]2CC3=CNC4=C3C=CC=C4)C2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for L-364,373

分析证书/产品说明书

化学品安全技术说明书

参考文献 for L-364,373

参考文献是支持产品生物活性的出版物。

Seebohm et al (2003) Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ.Res. 93 941 PMID: 14576198

Jow et al (2006) Rb⁺ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev.Technol. 4 443 PMID: 16945016

Salata et al (1998) A novel benzodiazepine that activates cardiac slow delayed rectifier K⁺ currents. Am.Soc.Pharmacol.Exp.Ther. 53 220

Chadha et al (2012) Pharmacological dissection of K(V)7.1 channels in systemic and pulmonary arteries. Br.J.Pharmacol. 166 1377 PMID: 22251082

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