L-365,260

Cat. No. 2767 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective CCK₂ antagonist

化学名： N-[(3R)-2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)urea

纯度： ≥99% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for L-365,260

L-365,260 is a selective cholecystokinin receptor 2 (CCK₂) antagonist (IC₅₀ values are 2 and 280 nM at CCK₂ and CCK₁ receptors respectively) that is inactive at a range of other receptors including opiate, muscarinic acetylcholine, α- and β adrenergic, histamine, angiotensin and bradykinin receptors.

技术数据 for L-365,260

分子量	398.46
公式	C₂₄H₂₂N₄O₂
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	118101-09-0
PubChem ID	5311201
InChI Key	KDFQABSFVYLGPM-QFIPXVFZSA-N
Smiles	O=C1[C@H](NC(NC4=CC=CC(C)=C4)=O)N=C(C3=CC=CC=C3)C2=C(C=CC=C2)N1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for L-365,260

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	39.85	100
	ethanol	39.85	100

制备储备液 for L-365,260

以下数据基于产品分子量 398.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.55 mL	25.1 mL
5 mM	0.5 mL	2.51 mL	5.02 mL
10 mM	0.25 mL	1.25 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for L-365,260

分析证书/产品说明书

化学品安全技术说明书

参考文献 for L-365,260

参考文献是支持产品生物活性的出版物。

Kees et al (1989) Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260. J.Med.Chem. 32 13 PMID: 2909725

Lotti and Chang (1989) A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260. Eur.J.Pharmacol. 162 273 PMID: 2721567

Chung et al (2009) Cholecystokinin action on layer 6b neurons in somatosensory cortex. Brain Res. 1282 10 PMID: 19497313

If you know of a relevant reference for L-365,260, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 CCK₂ Receptor Antagonists

关键词: L-365,260, L-365,260 supplier, Selective, CCK2, antagonists, Cholecystokinin2, Receptors, L365260, Receptor, 2767, Tocris Bioscience

1 篇 L-365,260 的引用文献

引用文献是使用了 Tocris 产品的出版物。 L-365,260 的部分引用包括：

Wu et al (2014) Role of cholecystokinin in anorexia induction following oral exposure to the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol. Toxicol Sci 138 278 PMID: 24385417

您是否知道使用了 Tocris L-365,260 的优秀论文？请告知我们.

L-365,260 的评论

目前没有该产品的评论。 Be the first to review L-365,260 and earn rewards!

Have you used L-365,260?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.