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Submit ReviewL-690,330
说明： Inositol monophosphatase inhibitor
化学名： [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
生物活性 for L-690,330
L-690,330 is a potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.
许可信息
Sold with the permission of Merck Sharp and Dohme Ltd.
技术数据 for L-690,330
| 分子量 | 298.13 |
| 公式 | C8H12O8P2 |
| 储存 | Store at RT |
| CAS Number | 142523-38-4 |
| PubChem ID | 132449 |
| InChI Key | JKOCAAWWDVHWKB-UHFFFAOYSA-N |
| Smiles | CC(OC1=CC=C(O)C=C1)(P(O)(O)=O)P(O)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for L-690,330
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 5.96 | 20 |
制备储备液 for L-690,330
以下数据基于产品分子量 298.13。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 16.77 mL | 83.86 mL | 167.71 mL |
| 1 mM | 3.35 mL | 16.77 mL | 33.54 mL |
| 2 mM | 1.68 mL | 8.39 mL | 16.77 mL |
| 10 mM | 0.34 mL | 1.68 mL | 3.35 mL |
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产品说明书 for L-690,330
参考文献 for L-690,330
参考文献是支持产品生物活性的出版物。
Atack et al (1993) In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J.Neurochem. 60 652 PMID: 8380439
Atack et al (1994) Effects of L-690,488, a pro-drug of the bisphosphonate inisotol monophosphatase inhibitor L-690,330, on phosphatidylinisotol cycle markers. J.Pharmacol.Exp.Ther. 270 70 PMID: 8035344
Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9 PMID: 21164513
Sarkar et al (2005) Li induces autophagy by inhibiting inositol monophosphatase. J.Cell.Biol. 170 1101 PMID: 16186256
If you know of a relevant reference for L-690,330, please let us know.
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关键词: L-690,330, L-690,330 supplier, Inositol, monophosphatase, inhibitors, inhibits, PIP2, Lipids, Ins145P3, 5-Phosphatase, IMPase, Phosphatases, L690330, Autophagy, 0681, Tocris Bioscience
6 篇 L-690,330 的引用文献
引用文献是使用了 Tocris 产品的出版物。 L-690,330 的部分引用包括：
Westfall et al (2003) Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol 162 889 PMID: 12952939
Sarkar et al (2005) Li induces autophagy by inhibiting inositol monophosphatase. Infect Immun 170 1101 PMID: 16186256
Sarkar et al (2008) A rational mechanism for combination treatment of Huntington's disease using Li and rapamycin. J Cell Biol 17 170 PMID: 17921520
Criollo et al (2007) Regulation of autophagy by the inositol trisphosphate receptor. Cell Death Differ 14 1029 PMID: 17256008
Meyer et al (2011) Inhibition of inositol monophosphatase by Li chloride induces selective macrophage apoptosis in atherosclerotic plaques. Br J Pharmacol 162 1410 PMID: 21138421
Harding et al (2013) LtpD is a novel Legionella pneumophila effector that binds phosphatidylinositol 3-phosphate and inositol monophosphatase IMPA1. Infect Immun 81 4261 PMID: 24002062
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