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Inositol Lipids

Inositol lipids are the structural basis of many second messenger molecules in eukaryotic cells, such as inositol monophosphate, inositol triphosphate (IP3) and inositol 1,4,5-trisphosphate (Ins (1,4,5)P3). Inositol lipid signaling pathways are regulated by phosphorylation.

Products
Background
Gene Data

Inositol Lipid Antagonists
Cat. No. Product Name / Activity
1224 2-APB
IP3 receptor antagonist; also TRP channel modulator

Inositol Lipid Inhibitors
Cat. No. Product Name / Activity
4839 AZD 6482
Potent and selective PI 3-Kβ inhibitor
3606 BAG 956
Dual PI 3-kinase and PDPK1 (PDK1) inhibitor
0681 L-690,330
Inositol monophosphatase inhibitor
1130 LY 294002 hydrochloride
Prototypical PI 3-kinase inhibitor; also inhibits other kinases
3977 3-Methyladenine
Class III PI 3-kinase inhibitor; also inhibits autophagy
2930 PI 103 hydrochloride
Inhibitor of PI 3-kinase, mTOR and DNA-PK
2814 PI 828
PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)
1125 Quercetin
Non-selective PI 3-kinase inhibitor
3946 TNP
Inhibitor of IP6K; also inhibits IP3K
1232 Wortmannin
Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1

Inositol Lipid Activators
Cat. No. Product Name / Activity
1983 740 Y-P
Cell-permeable PI 3-kinase activator

Other
Cat. No. Product Name / Activity
1482 D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt
Ca2+ mobilizing second messenger

Related Targets

Inositol lipids are the structural basis of many second messenger molecules in eukaryotic cells, such as inositol monophosphate, inositol triphosphate (IP3) and inositol 1,4,5-trisphosphate (Ins (1,4,5)P3).

In response to GPCR and receptor tyrosine kinase activation, PI 3-kinase phosphorylates some inositol lipids, such as PI(3,4,5)P3, and PLC mediates inositol lipid cleavage to generate further second messengers such as DAG and IP3. IP3 subsequently acts upon IP3 receptors located in the ER membrane and mediates Ca2+ release.

Regulation of inositol lipid signaling pathways is through phosphorylation (e.g. by inositol-tetrakisphosphate 1-kinase) and dephosphorylation (e.g. by inositol monophosphatase (IMPase)) of inositol lipids. This large group of proteins constitute a major intracellular signal transduction network. Because of this, inositol lipids are involved in a vast number of physiological processes.

Inositol Lipid Signaling Pathway Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
IMPase 1 Human IMPA1 NM_005536 P29218
Mouse Impa1 NM_018864 O55023
Rat Impa1 NM_032057 P97618
IMPase 2 Human IMPA2 NM_014214 O14732
Mouse Impa2 NM_053261 Q91UZ5
Rat Impa2 NM_172224 Q8CIN7
Inositol Polyphosphate-1-Phosphatase Human INPP1 NM_001128928 P49441
Mouse Inpp1 NM_008384 P49442
Rat Inpp1 NM_001012131 Q5RJK6
Inositol Hexakisphosphate Kinase 1 Human IP6K1 NM_153273 Q92551
Mouse Ip6k1 NM_013785 Q6PD10
Rat Ip6k1 NM_053316 Q9ESM0
Inositol Polyphosphate Multikinase Human IPMK NM_152230 Q8NFU5
Mouse Ipmk NM_027184 Q7TT16
Rat Ipmk NM_134417 Q99NI4
PI 3-K
Class IA
p85α, p50α, p55α 		Human PIK3R1 NM_181504 P27986
Mouse Pik3r1 NM_001077495 P26450
Rat Pik3r1 NM_013005 O55168
Class IA
p85β 		Human PIK3R2 NM_005027 O00459
Mouse Pik3r2 NM_008841 O08908
Rat Pik3r2 NM_022185 Q63788
Class IA
p55γ 		Human PIK3R3 NM_003629 Q92569
Mouse Pik3r3 NM_181585 Q64143
Rat Pik3r3 NM_022213 Q63789
Class IA
p110α 		Human PIK3CA NM_006218 P42336
Mouse Pik3ca NM_008839 P42337
Rat Pik3ca BC099154 Q4KLK3
Class IA
p110β 		Human PIK3CB NM_006219 P42338
Mouse Pik3cb NM_029094 Q8BTI9
Rat Pik3cb NM_053481 Q9Z1L0
Class IA
p110δ 		Human PIK3CD NM_005026 O00329
Mouse Pik3cd NM_008840 O35904
Class IB
p101 		Human PIK3R5 NM_014308 Q8WYR1
Mouse Pik3r5 NM_177320 Q5SW28
Class IB
p101γ 		Human PIK3CG NM_002649 P48736
Mouse Pik3cg NM_020272 Q9JHG7
Class II
C2α 		Human PIK3C2A NM_002645 O00443
Mouse Pik3c2a NM_011083 Q61194
Class II
C2β 		Human PIK3C2B NM_002646 O00750
Mouse Pik3c2b AK049181 A2RSK1
Class II
C2γ 		Human PIK3C2G NM_004570 O75747
Mouse Pik3c2g NM_207683 O70167
Rat Pik3c2g NM_053923 O70173
Class III
p150 		Human PIK3R4 NM_014602 Q99570
Mouse Pik3r4 NM_001081309 Q8VD65
Class III
Vps34 		Human PIK3C3 NM_002647 Q8NEB9
Mouse Pik3c3 NM_181414 Q6PF93
Rat Pik3c3 NM_022958 O88763
PLC
PLCβ1 Human PLCB1 NM_015192 Q9NQ65
Mouse Plcb1 NM_019677 Q9Z1B3
Rat Plcb1 NM_001077641 P10687
PLCβ2 Human PLCB1 NM_004573 Q00722
Mouse Plcb2 NM_177568 A3KGF7
Rat Plcb2 NM_053478 O89040
PLCβ3 Human PLCB3 NM_000932 Q01970
Mouse Plcb3 NM_008874 P51432
Rat Plcb3 NM_033350 Q45QJ4
PLCβ4 Human PLCB4 NM_000933 Q9UJQ2
Mouse Plcb4 NM_013829 NP_038857
Rat Plcb4 NM_024353 Q9QW07
PLCγ1 Human PLCG1 NM_182811 P19174
Mouse Plcg1 NM_021280 Q62077
Rat Plcg1 NM_013187 P10686
PLCγ2 Human PLCG2 NM_002661 P16885
Mouse Plcg2 NM_172285 Q8CIH5
Rat Plcg2 NM_017168 P24135
PLCδ1 Human PLCD1 NM_006225 P51178
Mouse Plcd1 NM_019676 Q8R3B1
Rat Plcd1 NM_017035 P10688
PLCδ3 Human PLCD3 NM_133373 Q8N3E9
Mouse Plcd3 NM_152813 Q8K2J0
Rat Plcd3 NM_001105845 XP_221004
PLCδ4 Human PLCD4 NM_032726 Q9BRC7
Mouse Plcd4 NM_148937 Q8K3R3
Rat Plcd4 NM_080688 Q62711
PLCε1 Human PLCE1 NM_016341 Q9P212
Mouse Plce1 NM_019588 Q8K4S1
Rat Plce1 NM_053758 Q99P84
PLCζ1 Human PLCZ1 NM_033123 Q86YW0
Mouse Plcz1 NM_054066 Q8K4D7
Rat Plcz1 NM_001012234 Q5FX52
PLCη1 Human PLCH1 NM_014996 Q4KWH8
Mouse Plch1 NM_183191 Q4KWH5
Rat Plch1 XM_227208 XP_227208
PLCη2 Human PLCH2 NM_014638 O75038
Mouse Plch2 NM_175556 A2AP18
Rat Plch2 XM_233728 XP_233728
IP3
IP3R1 Human ITPR1 NM_002222 Q14643
Mouse Itpr1 NM_010585 P11881
Rat Itpr1 NM_001007235 Q5BJS8
IP3R2 Human ITPR2 NM_002223 Q14571
Mouse Itpr2 NM_019923 Q9Z329
Rat Itpr2 NM_031046 Q6W3E4
IP3R3 Human ITPR3 NM_002224 Q14573
Mouse Itpr3 NM_080553 P70227
Rat Itpr3 NM_013138 Q63269