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Submit ReviewL-694,247
说明： 5-HT1D agonist
化学名： 2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine
纯度： ≥98% (HPLC)
生物活性 for L-694,247
L-694,247 is a selective and extremely potent 5-HT1D receptor agonist.
许可信息
Sold with the permission of Merck Sharp and Dohme Ltd.
技术数据 for L-694,247
| 分子量 | 411.48 |
| 公式 | C20H21N5O3S |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 137403-12-4 |
| PubChem ID | 132059 |
| InChI Key | HKXMQLISPYELRD-UHFFFAOYSA-N |
| Smiles | CS(=O)(=O)NC1=CC=C(CC2=NOC(=N2)C2=CC=C3NC=C(CCN)C3=C2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for L-694,247
参考文献 for L-694,247
参考文献是支持产品生物活性的出版物。
Beer et al (1993) L-694,247: a potent 5-HT1D receptor agonist. Br.J.Pharmacol. 110 1196 PMID: 8298808
Buhlen et al (1996) Evidence for presynaptic location of inhibitory 5-HT1Dβ -like autoreceptors in the guinea-pig brain cortex. Naunyn Schmiedebergs Arch.Pharmacol. 353 281 PMID: 8692282
Heald et al (1994) [3H]L-694,247 labels the 5-HT1Dβ receptor in pig caudate membranes. Eur.J.Pharmacol. 264 213 PMID: 7851485
Street et al (1993) Synthesis and serotonergic activity of 5-(oxadiazoyl)tryptamines: potent agonists of 5-HT1D receptors. J.Med.Chem. 36 1529 PMID: 8496922
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关键词: L-694,247, L-694,247 supplier, 5-HT1D, agonists, Serotonin, Receptors, L694247, merck, 0781, Tocris Bioscience
3 篇 L-694,247 的引用文献
引用文献是使用了 Tocris 产品的出版物。 L-694,247 的部分引用包括：
Hampson et al (2007) Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia 50 1743 PMID: 17579833
Bhalla et al (2001) Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor. Br J Pharmacol 133 891 PMID: 11454663
Geerts et al (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol 127 1327 PMID: 10455282
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.