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Submit ReviewL-701,252
说明： NMDA antagonist; acts at glycine site
化学名： 7-Chloro-3-(cyclopropylcarbonyl)-4-hydroxy-2(1H)-quinolinone
纯度： ≥99% (HPLC)
生物活性 for L-701,252
L-701,252 is a an antagonist at the glycine-NMDA site (IC50 = 420 nM). Also a potent systemic anticonvulsant.
许可信息
Sold with the permission of Merck Sharp and Dohme Ltd.
技术数据 for L-701,252
| 分子量 | 263.68 |
| 公式 | C13H10ClNO3 |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 151057-13-5 |
| PubChem ID | 54687453 |
| InChI Key | MXEFWCFPCLDOOG-UHFFFAOYSA-N |
| Smiles | OC1=C(C(=O)C2CC2)C(=O)NC2=C1C=CC(Cl)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for L-701,252
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 50 |
制备储备液 for L-701,252
以下数据基于产品分子量 263.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.58 mL | 37.92 mL | 75.85 mL |
| 2.5 mM | 1.52 mL | 7.58 mL | 15.17 mL |
| 5 mM | 0.76 mL | 3.79 mL | 7.58 mL |
| 25 mM | 0.15 mL | 0.76 mL | 1.52 mL |
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产品说明书 for L-701,252
参考文献 for L-701,252
参考文献是支持产品生物活性的出版物。
Rowley et al (1993) 3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the NMDA receptor complex. J.Med.Chem. 36 3386 PMID: 8230129
Stone (2000) Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. TiPS 21 149 PMID: 10740291
If you know of a relevant reference for L-701,252, please let us know.
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关键词: L-701,252, L-701,252 supplier, NMDA, antagonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, anticonvulsant, L701252, merck, 0705, Tocris Bioscience
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