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Submit ReviewL-701,324
说明： NMDA antagonist; acts at glycine site
化学名： 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
纯度： ≥99% (HPLC)
生物活性 for L-701,324
L-701,324 is a an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.
许可信息
Sold with the permission of Merck Sharp and Dohme Ltd.
技术数据 for L-701,324
| 分子量 | 363.8 |
| 公式 | C21H14ClNO3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 142326-59-8 |
| PubChem ID | 54682505 |
| InChI Key | FLVRDMUHUXVRET-UHFFFAOYSA-N |
| Smiles | OC1=C(C(=O)NC2=CC(Cl)=CC=C12)C1=CC=CC(OC2=CC=CC=C2)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for L-701,324
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 100 |
制备储备液 for L-701,324
以下数据基于产品分子量 363.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.75 mL | 13.74 mL | 27.49 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.5 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.75 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
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产品说明书 for L-701,324
参考文献 for L-701,324
参考文献是支持产品生物活性的出版物。
Bristow et al (1996) The atypical neuroleptic profile of the glycine/N-MthD.-aspartate receptor antagonist, L-701,324 in rodents. J.Pharmacol.Exp.Ther. 277 578 PMID: 8627534
Bristow et al (1996) Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-MthD.-aspartate receptor complex. J.Pharmacol.Exp.Ther. 279 492 PMID: 8930150
Kulagowski et al (1994) 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor. J.Med.Chem. 37 1402 PMID: 8182696
Obrenovitch and Zilkha (1996) Inhibition of cortical spreading depression by L-701,324, a novel antagonist at the glycine site of the N-MthD.-aspartate receptor complex. Br.J.Pharmacol. 117 931 PMID: 8851513
If you know of a relevant reference for L-701,324, please let us know.
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关键词: L-701,324, L-701,324 supplier, NMDA, antagonist, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, L701324, 0907, Tocris Bioscience
1 篇 L-701,324 的引用文献
引用文献是使用了 Tocris 产品的出版物。 L-701,324 的部分引用包括：
Bäckström and Hyytiä (2006) Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 31 778 PMID: 16123768
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