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Submit ReviewL-741,741 hydrochloride
说明： Potent, selective D4 antagonist
化学名： 3-(4-Chlorophenyl)-4-methyl-5-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride
纯度： ≥99% (HPLC)
生物活性 for L-741,741 hydrochloride
A potent and highly selective D4 dopamine receptor antagonist, with Ki values of > 1700, 480 and 2.5 nM at cloned human D2, D3 and D4 receptors respectively.
许可信息
Sold the permission of Merck Sharpe and Dohme Ltd.
技术数据 for L-741,741 hydrochloride
| 分子量 | 417.38 |
| 公式 | C23H25ClN2O.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| Smiles | ClC4=CC=C(C=C4)C1=NOC(C(CC3)CCN3CCC2=CC=CC=C2)=C1C.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for L-741,741 hydrochloride
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参考文献 for L-741,741 hydrochloride
参考文献是支持产品生物活性的出版物。
Rowley et al (1996) 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned DA D4 receptors. J.Med.Chem 39 1943 PMID: 8642551
Rowley et al (1997) 4-Heterocyclylpiperidines as selective high-affinity ligands at the human DA D4 receptor. J.Med.Chem. 40 2374 PMID: 9240352
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关键词: L-741,741 hydrochloride, L-741,741 hydrochloride supplier, D4, dopamine, antagonist, Receptors, 1005, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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