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Submit ReviewL-741,742 hydrochloride
说明： Highly selective D4 antagonist
化学名： 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride
纯度： ≥98% (HPLC)
生物活性 for L-741,742 hydrochloride
L-741,742 hydrochloride is a potent and highly selective D4 dopamine receptor antagonist, with Ki values of > 1700, 770 and 3.5 nM at cloned human D2, D3 and D4 receptors.
许可信息
Sold with the permission of Merck Sharp and Dohme Ltd.
技术数据 for L-741,742 hydrochloride
| 分子量 | 417.38 |
| 公式 | C23H25N2ClO.HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 874882-93-6 |
| PubChem ID | 133008 |
| InChI Key | QDMAKDIDFJTXEL-UHFFFAOYSA-N |
| Smiles | Cl.CC1=C(ON=C1C1CCN(CCC2=CC=CC=C2)CC1)C1=CC=C(Cl)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for L-741,742 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 4.17 | 10 |
制备储备液 for L-741,742 hydrochloride
以下数据基于产品分子量 417.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.96 mL | 119.79 mL | 239.59 mL |
| 0.5 mM | 4.79 mL | 23.96 mL | 47.92 mL |
| 1 mM | 2.4 mL | 11.98 mL | 23.96 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.79 mL |
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产品说明书 for L-741,742 hydrochloride
参考文献 for L-741,742 hydrochloride
参考文献是支持产品生物活性的出版物。
Rowley et al (1996) 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned DA D4 receptors. J. Med. Chem. 39 1943 PMID: 8642551
Rowley et al (1997) 4-Heterocyclylpiperidines as selective high-affinity ligands at the human DA D4 receptor. J.Med.Chem. 40 2374 PMID: 9240352
If you know of a relevant reference for L-741,742 hydrochloride, please let us know.
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关键词: L-741,742 hydrochloride, L-741,742 hydrochloride supplier, selective, D4, antagonists, Dopamine, Receptors, dopaminergic, L741742, 1004, Tocris Bioscience
3 篇 L-741,742 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 L-741,742 hydrochloride 的部分引用包括：
Root et al (2015) NE activates DA D4 receptors in the rat lateral habenula. J Neurosci 35 3460 PMID: 25716845
Bastianetto et al (2006) Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation. BMC Neurosci 7 28 PMID: 16573831
Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 829 PMID: 27300435
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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