L-745,870 trihydrochloride

Name: L-745,870 trihydrochloride
Brand: Tocris Bioscience
SKU: 1002
Rating: 5 (1 reviews)

Cat. No. 1002 13 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Highly selective D₄ antagonist

化学名： 3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (13)

文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for L-745,870 trihydrochloride

L-745,870 trihydrochloride is a highly potent and selective D₄ dopamine receptor antagonist; L-745,870 has K_i values of 0.51, 2300 and 960 nM for D₄, D₃ and D₂ subtypes respectively and > 1000-fold selectivity over 5-HT₂, D₁ and D₅ receptors.

许可信息

Sold with the permission of Merck Sharp and Dohme Ltd.

技术数据 for L-745,870 trihydrochloride

分子量	436.21
公式	C₁₈H₁₉N₄Cl.3HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	866021-03-6
PubChem ID	49759035
InChI Key	KJSOYZLYCFYXFC-UHFFFAOYSA-N
Smiles	Cl.Cl.Cl.ClC1=CC=C(C=C1)N1CCN(CC2=CNC3=NC=CC=C23)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for L-745,870 trihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	43.62	100

制备储备液 for L-745,870 trihydrochloride

以下数据基于产品分子量 436.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.29 mL	11.46 mL	22.92 mL
5 mM	0.46 mL	2.29 mL	4.58 mL
10 mM	0.23 mL	1.15 mL	2.29 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for L-745,870 trihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for L-745,870 trihydrochloride

参考文献是支持产品生物活性的出版物。

Bristow et al (1997) Schizophrenia and L-745, 870 a novel DA D₄ receptor antagonist. TiPS 18 186 PMID: 9226994

Kulagowski et al (1996) 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine: an antagonist with high affinity and selectivity for the human D₄ receptor. J.Med.Chem. 39 1941 PMID: 8642550

Patel et al (1997) Biological profile of L-745,870, a selective antagonist with high affinity for the DA D₄ receptor. J.Pharmacol.Exp.Ther. 283 636 PMID: 9353380

Pillai et al (1998) Human D2 and D4 DA receptors couple through βγ G-protein subunits to inwardly rectifying K+ channels (GIRK1) in a Xenopus oocyte expression system: selective antagonism by L-741,626 and L-745,870 respect Neuropharmacology 37 983 PMID: 9833627

If you know of a relevant reference for L-745,870 trihydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 D₄ Receptor Antagonists

关键词: L-745,870 trihydrochloride, L-745,870 trihydrochloride supplier, selective, D4, antagonists, Dopamine, Receptors, dopaminergic, L745870, 1002, Tocris Bioscience

13 篇 L-745,870 trihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 L-745,870 trihydrochloride 的部分引用包括：

Sharma et al (2021) Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model. Nat Commun 12 7293 PMID: 34911940

Huang (2017) Neurochemical arguments for the use of DA D4 receptor stimulation to improve cognitive impairment associated with schizophrenia. Pharmacol Biochem Behav 157 16 PMID: 28455127

Guo (2017) DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Aging Cell 16 1323 PMID: 28975698

Herwerth et al (2012) D4 DA receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1. Cereb Cortex 22 1786 PMID: 21955919

Chen et al (2015) Activation of D4 DA receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells. Autophagy 65 153 PMID: 25368031

Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769

Picton et al (2016) Mechanisms underlying the endogenous DArgic inhibition of spinal locomotor circuit function in Xenopus tadpoles. Scientific Reports 6 35749 PMID: 27760989

Jensen (2015) Effects of DA D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas. PLoS One 10 e0146154 PMID: 26717015

Suárez-Boomgaard et al (2014) DA D₄ receptor counteracts morphine-induced changes in µ opioid receptor signaling in the striosomes of the rat caudate putamen. Int J Mol Sci 15 1481 PMID: 24451133

Steullet et al (2014) Fast oscillatory activity in the anterior cingulate cortex: DArgic modulation and effect of perineuronal net loss. Front Cell Neurosci 8 244 PMID: 25191228

Dai et al (2017) Is DA transporter-mediated DArgic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel DA transporter variant Val559 transgenic mouse model. J Neurodev Disord 9 38 PMID: 29281965

Okada et al (2005) A DA D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein. Hypertension 25 794 PMID: 15729293

Basso et al (2005) Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test. Neuropsychopharmacology 30 1257 PMID: 15688083

您是否知道使用了 Tocris L-745,870 trihydrochloride 的优秀论文？请告知我们.

L-745,870 trihydrochloride 的评论

平均评分: 5 (Based on 1 Review.)

5 星

100%

4 星

3 星

2 星

1 星

Have you used L-745,870 trihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Inhibition of Synaptic Transmission in the VP.

By Anonymous on 02/02/2020

分析类型： In Vivo

种属： Mouse

L-745870 (100 nM)

PMID: 29949769

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.