L-748,337

Cat. No. 2760 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective β₃ antagonist

化学名： N-[[3-[(2S)-2-Hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl]-acetamide

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for L-748,337

L-748,337 is a competitive β₃-adrenoceptor antagonist that displays selectivity over β₁ and β₂ receptors (K_i values are 4.0, 204 and 390 nM for β₃-, β₂- and β₁-adrenoceptors respectively). Inhibits cAMP accumulation in response to Isoproterenol (IC₅₀ = 6 nM). Reduces iNOS expression, attenuates nitric oxide-induced cell proliferation and induces apoptosis in a melanoma cell line.

化合物库 for L-748,337

L-748,337 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for L-748,337

分子量	497.61
公式	C₂₆H₃₁N₃O₅S
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	244192-94-7
PubChem ID	10028830
InChI Key	AWIONHVPTYTSHZ-DEOSSOPVSA-N
Smiles	O[C@H](COC2=CC=CC(CNC(C)=O)=C2)CNCCC1=CC=C(NS(=O)(C3=CC=CC=C3)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for L-748,337

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	49.76	100
	ethanol	4.98	10

制备储备液 for L-748,337

以下数据基于产品分子量 497.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.01 mL	10.05 mL	20.1 mL
5 mM	0.4 mL	2.01 mL	4.02 mL
10 mM	0.2 mL	1 mL	2.01 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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产品说明书 for L-748,337

分析证书/产品说明书

化学品安全技术说明书

参考文献 for L-748,337

参考文献是支持产品生物活性的出版物。

Candelore et al (1999) Potent and selective human β₃-adrenergic receptor antagonist. J.Pharmacol.Exp.Ther. 290 649 PMID: 10411574

Neidhold et al (2007) The function of α- and β-adrenoceptors of the saphenous artery in caveolin-1 knockout and wild-type mice. Br.J.Pharmacol. 150 261 PMID: 17179950

Dal Monte et al (2014) β3-adrenergic receptor activity modulates melanoma cell proliferation and survival through nitric oxide signaling. Naunyn Schmiedebergs Arch.Pharmacol. 387 533 PMID: 24599317

If you know of a relevant reference for L-748,337, please let us know.

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关键词: L-748,337, L-748,337 supplier, Selective, β3-adrenoceptor, b3-adrenoceptor, antagonists, β3-adrenergic, b3-adrenergic, Receptors, Adrenoceptors, L748337, Adrenergic, Beta-3, 2760, Tocris Bioscience

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